Evidence map›Paper›PMID 25520210›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2015

The relation of SMI and the VSEP in a risk sample for neurodegenerative disorders.

Katja Hagen, Ann-Christine Ehlis, Florian B Haeussinger, Stefan Beeretz, Gina V Kromer, Sebastian Heinzel, Walter Maetzler, Gerhard W Eschweiler, Daniela Berg, Andreas J Fallgatter and 2 more

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
  4. Article
  5. Review
  6. Article
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Katja HagenGerman Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany, hagen.katja@yahoo.de.
Ann-Christine Ehlis
Florian B Haeussinger
Stefan Beeretz
Gina V Kromer
Sebastian Heinzel
Walter Maetzler
Gerhard W Eschweiler
Daniela Berg
Andreas J Fallgatter
Florian G Metzger
TREND Study Consortium
University of Tübingen · DEHertie Institute for Clinical Brain Research · DEGerman Center for Neurodegenerative Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vagus somatosensory evoked potentials (VSEP) have been shown to have higher latencies with aging, which are even more increased in patients with Alzheimer's disease and subjects with mild cognitive impairment compared to age-matched healthy controls. In this study, the association of VSEP with subjective memory impairment (SMI), a potential risk or prodromal marker for Alzheimer's disease, was examined. The association of VSEP latencies and SMI was studied in a healthy risk cohort, including 358 elderly subjects, who are in a longitudinal study of risk factors for neurodegenerative disorders. The results show increased VSEP latencies for peak P2 at Fz-F4 in subjects who report SMI and are worried about it as compared to subjects who report memory impairment, but are not concerned and subjects without complaints. The results support a potential role of VSEP for the detection of very early neurodegenerative processes which may precede Alzheimer's disease.

Indexed as

Alzheimer DiseaseCognitive DysfunctionEvoked Potentials, SomatosensoryFemaleHumansMaleMemory DisordersMiddle AgedNeurodegenerative DiseasesPerceptionProspective StudiesRiskVagus Nerve

Identifiers

PMID25520210
OpenAlexW1988349897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.