ArticleEnvironmental science and pollution research international2015
Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China.
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Cuproptosis: Mechanisms, biological significance, and advances in disease treatment-A systematic review.CNS neuroscience & therapeutics · 2024Pooled it
- Chromium as a Risk Factor for Breast Cancer: A Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2022Pooled it
- Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Inhibition of PINK1/Parkin-mediated mitophagy enhances the susceptibility of breast cancer to cuproptosis.Oncogene · 2026Article
- FDX1 as a predictive biomarker and therapeutic target for lymph node metastasis in gastric cancer.Clinical and experimental medicine · 2026Article
- Role of cuproptosis in digestive system tumors (Review).International journal of molecular medicine · 2026Review
- ZNF384-regulated SLC31A1 expression promotes tumor proliferation and invasion in breast cancer.Molecular and cellular biochemistry · 2026Article
- Cuproptosis scoring system identifies novel molecular subtypes and modulates biological behavior in breast cancer.Discover oncology · 2025Article
- Integrating cuproptosis and immunosenescence: A novel therapeutic strategy in cancer treatment.Biochemistry and biophysics reports · 2025Review
- Low-Invasive Biomarkers of Canine Mammary Tumours.Veterinary medicine and science · 2025Review
- Copper-Induced Enhancement of Glioblastoma Tumorigenicity via Cytochrome C Oxidase.Antioxidants (Basel, Switzerland) · 2025Article
- A Novel Cuproptosis-Related Gene Signature Predicts Prognosis in Papillary Thyroid Carcinoma Patients.Combinatorial chemistry & high throughput screening · 2025Article
- The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer.PloS one · 2025Article
- Serum and tissue metallome of pancreatic ductal adenocarcinoma.Cancer science · 2024Article
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- Role of SLC31A1 in prognosis and immune infiltration in breast cancer: a novel insight.International journal of clinical and experimental pathology · 2024Article
- Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation.RSC advances · 2023Review
- Cuproptosis-related lncRNAs predict the prognosis and immune response in hepatocellular carcinoma.Clinical and experimental medicine · 2023Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental and epidemiological studies suggest that serum levels of trace elements may be associated with breast cancer risk. We compared serum levels of 15 trace elements between breast cancer patients and normal controls from Shandong, China, for the first time to assess whether serum levels of trace elements were associated with breast cancer risk. Eighty-eight breast cancer patients and 84 healthy controls were enrolled in the study. A Spectraspan V direct current plasma atomic emission spectrometer was used to determine the serum levels of 15 trace elements including Zn, Mn, Al, Cd, Fe, Mg, Ca, Pb, Cu, Se, Ni, Ti, Co, Li, and Cr. Breast cancer patients had significantly higher serum levels of Cd (p = 0.000), Mg (p = 0.001), Cu (p = 0.000), Co (p = 0.006), and Li (p = 0.003) and borderline higher Cr (p = 0.052), while significantly lower Mn (p = 0.000), Al (p = 0.000), Fe (p = 0.000), and Ti (p = 0.000) compared to their matched controls. However, there were no significant differences in serum levels of Zn (p = 0.824), Ca (p = 0.711), Pb (p = 0.274), Se (p = 0.236), and Ni (p = 0.185) between the two groups. Our study showed a possible association between serum levels of trace elements and breast cancer risk in eastern China, though it warrants further investigations to confirm the association. If confirmed, modulation of trace elements may help reduce breast cancer risk.
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Registered trials
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