Evidence map›Paper›PMID 25520163›Full record

SynthesisJournal of psychiatry & neuroscience : JPN2015

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies.

Rebekah Wigton, Jocham Radua, Paul Allen, Bruno Averbeck, Andreas Meyer-Lindenberg, Philip McGuire, Sukhi S Shergill, Paolo Fusar-Poli

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatry & neuroscience : JPN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 4 pooled it
41.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 182 citations in OpenAlex.

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  15. Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
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  17. Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Rebekah WigtonThe Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
Jocham RaduaThe Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK and Fidmag, Cibersam, Sant Boi de Llobregat, Barcelona, Spain.
Paul AllenThe Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
Bruno AverbeckLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Andreas Meyer-LindenbergCentral Institute of Mental Health, Medical Faculty Mannheim-Heidelberg University, Mannheim, Germany.
Philip McGuireDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
Sukhi S ShergillDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
Paolo Fusar-PoliDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
King's College London · GBNational Institutes of Health · USNational Institute of Mental Health · US

Funding

Frontal Striatal Systems and Dopamine in Normal and Pathological BehaviorZIAMH002928 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI AVERBECK, BRUNO · 2010 to 2025
$29.0M
6 · The paper itself

Abstract

backgroundOxytocin (OXT) plays a prominent role in social cognition and may have clinical applications for disorders such as autism, schizophrenia and social anxiety. The neural basis of its mechanism of action remains unclear.

methodsWe conducted a systematic literature review of placebo-controlled imaging studies using OXT as a pharmacological manipulator of brain activity.

resultsWe identified a total of 21 studies for inclusion in our review, and after applying additional selection criteria, 11 of them were included in our fMRI voxel-based meta-analysis. The results demonstrate consistent alterations in activation of brain regions, including the temporal lobes and insula, during the processing of social stimuli, with some variation dependent on sex and task. The meta-analysis revealed significant left insular hyperactivation after OXT administration, suggesting a potential modulation of neural circuits underlying emotional processing. LIMITATIONS: This quantitative review included only a limited number of studies, thus the conclusions of our analysis should be interpreted cautiously. This limited sample size precluded a more detailed exploration of potential confounding factors, such as sex or other demographic factors, that may have affected our meta-analysis.

conclusionOxytocin has a wide range of effects over neural activity in response to social and emotional processing, which is further modulated by sex and task specificity. The magnitude of this neural activation is largest in the temporal lobes, and a meta-analysis across all tasks and both sexes showed that the left insula demonstrated the most robust activation to OXT administration.

Indexed as

AnimalsBrainBrain MappingCentral Nervous System AgentsElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleOxytocinSex CharacteristicsCentral Nervous System AgentsOxytocin

Identifiers

PMID25520163
PMCPMC4275335
OpenAlexW2167182003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.