ArticleBMC genomics2014
Discovery of osmotic sensitive transcription factors in fish intestine via a transcriptomic approach.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Prolactin, cortisol, and extracellular osmolality regulateFrontiers in endocrinology · 2026Article
- Adaptation responses to salt stress in the gut ofAnimal cells and systems · 2025Article
- Osmosensitive transcription factors in the prolactin cell of a euryhaline teleost.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2023Article
- Prediction and Experimental Validation of a New Salinity-Responsive Cis-Regulatory Element (CRE) in a Tilapia Cell Line.Life (Basel, Switzerland) · 2022Article
- Integrated Omics Approaches Revealed the Osmotic Stress-Responsive Genes and Microbiota in Gill of Marine Medaka.mSystems · 2022Article
- Recent progress in the understanding of the gut microbiota of marine fishes.Marine life science & technology · 2021Review
- Gill Transcriptome Analysis Revealed the Difference in Gene Expression Between Freshwater and Seawater Acclimated Guppy (Poecilia reticulata).Marine biotechnology (New York, N.Y.) · 2021Article
- The digestive tract as an essential organ for water acquisition in marine teleosts: lessons from euryhaline eels.Zoological letters · 2021Review
- Transcriptional regulation of prolactin in a euryhaline teleost: Characterisation of gene promoters through in silico and transcriptome analyses.Journal of neuroendocrinology · 2020Review
- RNA-seq analysis reveals divergent adaptive response to hyper- and hypo-salinity in cobia, Rachycentron canadum.Fish physiology and biochemistry · 2020Article
- Transcriptomic response to three osmotic stresses in gills of hybrid tilapia (Oreochromis mossambicus female × O. urolepis hornorum male).BMC genomics · 2020Article
- Network of microRNA-transcriptional factor-mRNA in cold response of turbot Scophthalmus maximus.Fish physiology and biochemistry · 2019Article
- Phylogeography and Ecological Niche Shape the Cichlid Fish Gut Microbiota in Central American and African Lakes.Frontiers in microbiology · 2019Article
- Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis.BMC genomics · 2018Article
- Osmolality/salinity-responsive enhancers (OSREs) control induction of osmoprotective genes in euryhaline fish.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A sodium binding system alleviates acute salt stress during seawater acclimation in eels.Zoological letters · 2017Article
- Gene Expression Profiling Reveals Functional Specialization along the Intestinal Tract of a Carnivorous Teleostean Fish (Dicentrarchus labrax).Frontiers in physiology · 2016Article
- Flexible selection of diversified Na(+)/K(+)-ATPase α-subunit isoforms for osmoregulation in teleosts.Zoological letters · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTeleost intestine is crucial for seawater acclimation by sensing osmolality of imbibed seawater and regulating drinking and water/ion absorption. Regulatory genes for transforming intestinal function have not been identified. A transcriptomic approach was used to search for such genes in the intestine of euryhaline medaka.
resultsQuantitative RNA-seq by Illumina Hi-Seq Sequencing method was performed to analyze intestinal gene expression 0 h, 1 h, 3 h, 1 d, and 7 d after seawater transfer. Gene ontology (GO) enrichment results showed that cell adhesion, signal transduction, and protein phosphorylation gene categories were augmented soon after transfer, indicating a rapid reorganization of cellular components and functions. Among >50 transiently up-regulated transcription factors selected via co-expression correlation and GO selection, five transcription factors, including CEBPB and CEBPD, were confirmed by quantitative PCR to be specific to hyperosmotic stress, while others were also up-regulated after freshwater control transfer, including some well-known osmotic-stress transcription factors such as SGK1 and TSC22D3/Ostf1. Protein interaction networks suggest a high degree of overlapping among the signaling of transcription factors that respond to osmotic and general stresses, which sheds light on the interpretation of their roles during hyperosmotic stress and emergency.
conclusionsSince cortisol is an important hormone for seawater acclimation as well as for general stress in teleosts, emergency and osmotic challenges could have been evolved in parallel and resulted in the overlapped signaling networks. Our results revealed important interactions among transcription factors and offer a multifactorial perspective of genes involved in seawater acclimation.
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