ArticleJournal of the Royal Society, Interface2015
Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Mathematical models for dengue fever epidemiology: A 10-year systematic review.Physics of life reviews · 2022Pooled it
- Methotrexate's effect on cells and adalimumab immunogenicity in axial spondyloarthritis: A mathematical study.PLoS computational biology · 2026Article
- In-host modeling of dengue virus and non-structural protein 1 and the effects of ivermectin in patients with acute dengue fever.CPT: pharmacometrics & systems pharmacology · 2024Article
- Identifiability investigation of within-host models of acute virus infection.Mathematical biosciences and engineering : MBE · 2024Article
- Modelling the mechanisms of antibody mixtures in viral infections: the cases of sequential homologous and heterologous dengue infections.Journal of the Royal Society, Interface · 2024Article
- Within-host models unravelling the dynamics of dengue reinfections.Infectious Disease Modelling · 2024Article
- Association of systemic vitamin D on the course of dengue virus infection in adults: a single-centre dengue cohort study at a large institution in Singapore.Singapore medical journal · 2024Article
- Identifiability investigation of within-host models of acute virus infection.bioRxiv : the preprint server for biology · 2024Article
- Incorporating Intracellular Processes in Virus Dynamics Models.Microorganisms · 2024Review
- How robust are estimates of key parameters in standard viral dynamic models?PLoS computational biology · 2024Article
- Global stability of secondary DENV infection models with non-specific and strain-specific CTLs.Heliyon · 2024Article
- The Mathematical Modeling of the Host-Virus Interaction in Dengue Virus Infection: A Quantitative Study.Viruses · 2024Article
- Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.PLoS computational biology · 2023Article
- COVID-19 dynamics and immune response: Linking within-host and between-host dynamics.Chaos, solitons, and fractals · 2023Article
- Heterogeneity of Rift Valley fever virus transmission potential across livestock hosts, quantified through a model-based analysis of host viral load and vector infection.PLoS computational biology · 2022Article
- Combining rapid diagnostic tests to estimate primary and post-primary dengue immune status at the point of care.PLoS neglected tropical diseases · 2022Article
- Data analysis and prediction of the COVID-19 outbreak in the first and second waves for top 5 affected countries in the world.Nonlinear dynamics · 2022Article
- Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A.ACS pharmacology & translational science · 2021Article
- Article
- Boosting can explain patterns of fluctuations of ratios of inapparent to symptomatic dengue virus infections.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In recent years, the within-host viral dynamics of dengue infections have been increasingly characterized, and the relationship between aspects of these dynamics and the manifestation of severe disease has been increasingly probed. Despite this progress, there are few mathematical models of within-host dengue dynamics, and the ones that exist focus primarily on the general role of immune cells in the clearance of infected cells, while neglecting other components of the immune response in limiting viraemia. Here, by considering a suite of mathematical within-host dengue models of increasing complexity, we aim to isolate the critical components of the innate and the adaptive immune response that suffice in the reproduction of several well-characterized features of primary and secondary dengue infections. By building up from a simple target cell limited model, we show that only the innate immune response is needed to recover the characteristic features of a primary symptomatic dengue infection, while a higher rate of viral infectivity (indicative of antibody-dependent enhancement) and infected cell clearance by T cells are further needed to recover the characteristic features of a secondary dengue infection. We show that these minimal models can reproduce the increased risk of disease associated with secondary heterologous infections that arises as a result of a cytokine storm, and, further, that they are consistent with virological indicators that predict the onset of severe disease, such as the magnitude of peak viraemia, time to peak viral load, and viral clearance rate. Finally, we show that the effectiveness of these virological indicators to predict the onset of severe disease depends on the contribution of T cells in fuelling the cytokine storm.
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