Evidence map›Paper›PMID 25519690›Full record

SynthesisDigestive diseases and sciences2015

Balloon-Occluded Retrograde Transvenous Obliteration (BRTO) for Treatment of Gastric Varices: Review and Meta-Analysis.

Jonathan K Park, Sammy Saab, Stephen T Kee, Ronald W Busuttil, Hyun J Kim, Francsico Durazo, Sung-Ki Cho, Edward Wolfgang Lee

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04828369 completednot on this mapstarted 2020, after this paper: background citation

Efficacy and Safety of EUS-Guided Coil Embolization Combined With Endoscopic Cyanoacrylate Injection Versus Balloon-Occluded Retrograde Transvenous Obliteration for Gastric Varices With High-risk Ectopic Embolism

TypeobservationalSponsorRenmin Hospital of Wuhan UniversityRan2020 to 2021Enrolled104ConditionsPortal Hypertension, Liver Cirrhosis, Gastric Varix, Portosystemic ShuntArmsEUS-guided coil embolization combined with endoscopic cyanoacrylate injection, balloon-occluded retrograde transvenous obliteration
NCT06106971 phase3unknown statusnot on this mapstarted 2018, after this paper: background citation

Balloon-occluded Retrograde Transvenous Obliteration Versus Endoscopic Tissue Glue Injection in the Prevention of Recurrent Gastric Variceal Bleeding

TypeinterventionalSponsorKaohsiung Veterans General Hospital.Ran2018 to 2025Enrolled68ConditionsGastric Varices Bleeding, Liver DecompensationArmsSodium tetradecyl sulfate, Cyanoacrylate
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.

  1. Guideline
  2. Radiologic Interventions for Gastrointestinal Bleeding.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
  3. Observational
  4. Article
  5. Article
  6. BRTO: Past, Present, and Future Directions.Interventional radiology (Higashimatsuyama-shi (Japan) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. [Endoscopic Treatment and Prevention of Acute Variceal Hemorrhage].The Korean journal of helicobacter and upper gastrointestinal research · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Management of Patients With Gastric Varices.Gastroenterology & hepatology · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jonathan K ParkUCLA Medical Center, Los Angeles, CA, USA.
Sammy Saab
Stephen T Kee
Ronald W Busuttil
Hyun J Kim
Francsico Durazo
Sung-Ki Cho
Edward Wolfgang Lee
Ronald Reagan UCLA Medical Center · USUCLA Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo perform a systematic review and meta-analysis of the effectiveness and complications of BRTO for gastric varices. MATERIALS AND

methodsA systematic review was performed to identify relevant articles. Inclusion criteria were applied to select studies with at least ten patients with acute bleeding or at-risk gastric varices treated with BRTO. Meta-analysis with random effects model was performed to calculate data for immediate technical success, clinical success, and complications.

resultsA total of 1,016 Patients from 24 studies met inclusion criteria. Technical success rate for BRTO was 96.4 % (95 % CI 93.7, 98.3 %; Q = 3,269.26, p < 0.01, I (2) = 99.39 %). Clinical success (defined as no recurrence or rebleed of gastric varices, or complete obliteration of varices on subsequent imaging) rate was 97.3 % (95 % CI 95.2, 98.8 %; Q = 3,105.91, p < 0.01, I (2) = 99.29 %). Major complication rate was 2.6 % (95 % CI 1.1, 4.6 %; Q = 3,348.98, p < 0.01, I (2) = 99.34 %). Esophageal variceal recurrence rate was 33.3 % (95 % CI 24.6, 42.6 %; Q = 7,291.75, p < 0.01, I (2) = 99.74 %).

conclusionBRTO is safe and efficacious for gastric varices, and current best evidence suggests that BRTO could be considered as therapy for patients with gastric varices.

Indexed as

Balloon OcclusionEsophageal and Gastric VaricesHumansPostoperative ComplicationsRecurrence

Identifiers

PMID25519690
OpenAlexW2017866851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.