ArticleBMC complementary and alternative medicine2014
Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Medicinal activities of Tualang honey: a systematic review.BMC complementary medicine and therapies · 2024Pooled it
- Curative potential of resveratrol and pterostilbene against epoxy resin-induced reproductive toxicity in female rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Neuro-protective Potential of Honey: A Narrative Review.Current pharmaceutical design · 2026Review
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- Article
- Therapeutic exploration of polyherbal formulation against letrozole induced PCOS rats: A mechanistic approach.Heliyon · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
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- Article
- Kelulut Honey Ameliorates Oestrus Cycle, Hormonal Profiles, and Oxidative Stress in Letrozole-Induced Polycystic Ovary Syndrome Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Fetal programming:Aging · 2022Article
- Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use.Molecules (Basel, Switzerland) · 2022Review
- Potential Therapeutic Benefits of Honey in Neurological Disorders: The Role of Polyphenols.Molecules (Basel, Switzerland) · 2022Review
- The Natural Cryoprotectant Honey for Fertility Cryopreservation.Bioengineering (Basel, Switzerland) · 2022Review
- Protective Roles of Honey in Reproductive Health: A Review.Molecules (Basel, Switzerland) · 2021Review
- Physicochemical and Medicinal Properties of Tualang, Gelam and Kelulut Honeys: A Comprehensive Review.Nutrients · 2021Review
- The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality.Advances in experimental medicine and biology · 2021Article
- Role of Antioxidants in Alleviating Bisphenol A Toxicity.Biomolecules · 2020Review
- Protective effect of Tualang honey against cadmium-induced morphological abnormalities and oxidative stress in the ovary of rats.BMC complementary medicine and therapies · 2020Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the potential protective effects of Tualang honey against the toxicity effects induced by Bisphenol A (BPA) on pubertal development of ovaries.
methodsThis study was conducted on pre-pubertal female Sprague Dawley rats. Animals were divided into four groups (n = 8 in each group). Group I was administered with vehicle 0.2 ml of corn oil (Sigma-Aldrich, USA) using oral gavage daily for six weeks; these animals served as negative control (CO group), Group II was administered with BPA suspended in corn oil at 10 mg/kg body weight and served as positive control (PC group), Group III was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of BPA at 10 mg/kg (TH group) while Group IV was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of corn oil (THC group). Body weight of all animals were monitored weekly.
resultsThe BPA-exposed animals exhibited disruption of their estrus cycle, while those animals treated with BPA together with Tualang honey, exhibited an improvement in percentage of normal estrous cycle. Their ovaries had lower numbers of atretic follicles compared to the PC group but higher than the CO group.
conclusionsTualang honey has a potential role in reducing BPA-induced ovarian toxicity by reducing the morphological abnormalities of the ovarian follicles and improving the normal estrous cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.