ArticleBMC proceedings2014
Identity-by-descent graphs offer a flexible framework for imputation and both linkage and association analyses.
Article in BMC proceedings, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Kinpute: using identity by descent to improve genotype imputation.Bioinformatics (Oxford, England) · 2019Article
- Breeding histories and selection criteria for oilseed rape in Europe and China identified by genome wide pedigree dissection.Scientific reports · 2017Article
- Identity-by-descent estimation with population- and pedigree-based imputation in admixed family data.BMC proceedings · 2016Article
- Combining family- and population-based imputation data for association analysis of rare and common variants in large pedigrees.Genetic epidemiology · 2014Article
- Value of Mendelian laws of segregation in families: data quality control, imputation, and beyond.Genetic epidemiology · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We demonstrate the flexibility of identity-by-descent (IBD) graphs for genotype imputation and testing relationships between genotype and phenotype. We analyzed chromosome 3 and the first replicate of simulated diastolic blood pressure. IBD graphs were obtained from complete pedigrees and full multipoint marker analysis, facilitating subsequent linkage and other analyses. For rare alleles, pedigree-based imputation using these IBD graphs had a higher call rate than did population-based imputation. Combining the two approaches improved call rates for common alleles. We found it advantageous to incorporate known, rather than estimated, pedigree relationships when testing for association. Replacing missing data with imputed alleles improved association signals as well. Analyses were performed with knowledge of the underlying model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.