ArticleBMC proceedings2014
Kernel score statistic for dependent data.
Article in BMC proceedings, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Kalpra: A kernel approach for longitudinal pathway regression analysis integrating network information with an application to the longitudinal PsyCourse Study.Frontiers in genetics · 2022Article
- Family-based gene-environment interaction using sequence kernel association test (FGE-SKAT) for complex quantitative traits.Scientific reports · 2021Article
- Detecting responses to treatment with fenofibrate in pedigrees.BMC genetics · 2018Article
- Comparing strategies for combined testing of rare and common variants in whole sequence and genome-wide genotype data.BMC proceedings · 2016Article
- Testing genetic association with rare and common variants in family data.Genetic epidemiology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The kernel score statistic is a global covariance component test over a set of genetic markers. It provides a flexible modeling framework and does not collapse marker information. We generalize the kernel score statistic to allow for familial dependencies and to adjust for random confounder effects. With this extension, we adjust our analysis of real and simulated baseline systolic blood pressure for polygenic familial background. We find that the kernel score test gains appreciably in power through the use of sequencing compared to tag-single-nucleotide polymorphisms for very rare single nucleotide polymorphisms with <1% minor allele frequency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.