ArticleBMC musculoskeletal disorders2014
Are outcomes after total knee arthroplasty worsening over time? A time-trends study of activity limitation and pain outcomes.
Article in BMC musculoskeletal disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02947321 (GREAT Knee Pain Reduction Trial, Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
GREAT Knee Pain Reduction Trial, Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What proportion of people have long-term pain after total hip or knee replacement? An update of a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Development and Validation of a Machine Learning-Based Prediction of Chronic Postsurgical Pain Following Total Hip and Knee Arthroplasty: An Exploratory Study.Pain research & management · 2026Article
- Global mapping of institutional and hospital-based (Level II-IV) arthroplasty registries: a scoping review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Literature review of the causes of pain following total knee replacement surgery: prosthesis, inflammation and arthrofibrosis.EFORT open reviews · 2020Review
- Body-Self Unity With a New Hip or Knee: Understanding Total Joint Replacement Within an Embodiment Framework.ACR open rheumatology · 2019Review
- The prognostic value of pain catastrophizing in health-related quality of life judgments after Total knee arthroplasty.Health and quality of life outcomes · 2018Article
- Comparison of Low-, Moderate-, and High-Molecular-Weight Hyaluronic Acid Injections in Delaying Time to Knee Surgery.The Journal of arthroplasty · 2017Observational
- Patient-reported health outcomes after total hip and knee surgery in a Dutch University Hospital Setting: results of twenty years clinical registry.BMC musculoskeletal disorders · 2017Article
- Towards an understanding of the painful total knee: what is the role of patient biology?Current reviews in musculoskeletal medicine · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundTo examine whether function and pain outcomes of patients undergoing primary total knee arthroplasty (TKA) are changing over time.
methodsThe Mayo Clinic Total Joint Registry provided data for time-trends in preoperative and 2-year post-operative activity limitation and pain in primary TKA patients from 1993-2005. We used chi-square test and analysis for variance, as appropriate. Multivariable-adjusted analyses were done using logistic regression.
resultsIn a cohort of 7,229 patients who underwent primary TKA during 1993-2005, mean age was 68.4 years (standard deviation (SD), 9.8), mean BMI was 31.1 (SD, 6.0) and 55% were women. Crude estimates showed that preoperative moderate-severe overall limitation were seen in 7.3% fewer patients and preoperative moderate-severe pain in 2.7% more patients in 2002-05, compared to 1992-95 (p < 0.001 for both). At 2-years, crude estimates indicated that compared to 1992-95, moderate-severe post-TKA overall limitation was seen in 4.7% more patients and moderate-severe post-TKA pain in 3.6% more patients in 2002-05, both statistically significant (p ≤ 0.018) and clinically meaningful. In multivariable-adjusted analyses that adjusted for age, sex, anxiety, depression, Deyo-Charlson index, body mass index and preoperative pain/limitation, patients had worse outcomes 2-year post-TKA in 2002-2005 compared to 1993-95 with an odds ratio (95% confidence interval (CI); p-value) of 1.34 (95% CI: 1.02, 1.76, p = 0.037) for moderate-severe activity limitation and 1.79 (95% CI: 1.17, 2.75, p = 0.007) for moderate-severe pain.
conclusionPatient-reported function and pain outcomes after primary TKA have worsened over the study period 1993-95 to 2002-05. This time-trend is independent of changes in preoperative pain/limitation and certain patient characteristics.
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