ArticleInfectious diseases and therapy2014
Recurrent Lower Urinary Tract Infections Have a Detrimental Effect on Patient Quality of Life: a Prospective, Observational Study.
Article in Infectious diseases and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 2 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2020Pooled it
- Chinese herbal medicine for treating recurrent urinary tract infections in women.The Cochrane database of systematic reviews · 2015Pooled it
- Whole cranberry fruit powder supplement reduces the incidence of culture-confirmed urinary tract infections in females with a history of recurrent urinary tract infection: A 6-month multicenter, randomized, double-blind, placebo-controlled trial.The American journal of clinical nutrition · 2025Trial
- Individualized Traditional Chinese Medicine treatment antibiotics for recurrent urinary tract infections: a multicenter, randomized controlled study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Trial
- A post-trial follow-up study of pentosan polysulfate monotherapy on preventing recurrent urinary tract infection in women.Scientific reports · 2022Trial
- Feasibility and Research Insights From a Randomized Controlled Trial for Recurrent Urinary Tract Infection Prevention in Postmenopausal Women Using Vaginal Estrogen Therapy.Female pelvic medicine & reconstructive surgery · 2022Trial
- Rapid screening of urinary tract infections: quantitative flow cytometry versus dipstick testing in a hospital cohort.Infection · 2026Article
- Global Burden and Temporal Trends of Urinary Tract Infections in Women of Child-Bearing Age in 204 Countries and Territories: A Comprehensive Analysis from 1990 to 2021.International urogynecology journal · 2026Article
- Recurrent urinary tract infections in primary care: a qualitative study of women's experiences.BMC primary care · 2026Article
- 12-Years Real-Life Data on Successful Management of Recurrent Urinary Tract Infections by OM-89 and Its Impact on Bacterial Resistance.Urologia internationalis · 2026Article
- The sublingual vaccine MV140 is dominant over prophylactic antibiotics for the prevention of recurrent, uncomplicated urinary tract infections in adult women A cost-utility analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026Article
- From Dismissal to Partnership: Patient Experiences of Recurrent Urinary Tract Infection Healthcare Informed by the Theoretical Domains Framework and Behaviour Change Theory.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- A randomized, triple-blind, placebo-controlled, parallel study of the efficacy of D-mannose for urinary tract infection symptoms in women.Current urology · 2026Article
- Current Evidence on Safety, Efficacy and Efficiency of Sublingual Vaccine UromunePathogens (Basel, Switzerland) · 2025Review
- Full Validation of Pooled Antibiotic Susceptibility Testing Using CLSI Methods and Performance Criteria in UTI Pathogens.Antibiotics (Basel, Switzerland) · 2025Article
- The Impact of Gynecological Pathologies on Patients' Quality of Life from Menarche to Menopause-Literature Review.Journal of clinical medicine · 2025Review
- A Qualitative Secondary Analysis of Patient Health-Related Quality of Life in Bloodstream Infections by Source: Intra-abdominal, Urinary Tract, and Acute Bacterial Skin and Skin Structure Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Article
- Etiology and Risk Factors of Recurrent Urinary Tract Infections in Women in a Multidisciplinary Hospital in Romania.Microorganisms · 2025Article
- Epidemiology of urinary tract infections in the Middle East and North Africa, 1990-2021.Tropical medicine and health · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study investigated the effects of recurrent urinary tract infections (rUTI) and the impact of prophylaxis on rUTI and patients' quality of life (QoL).
methodsAltogether, 575 patients affected by rUTI were included in a 6-month observational study. QoL was assessed using the Hospital Anxiety and Depression (HAD) and the Leicester scales. Statistical analyses were performed using SAS
resultsIn total, 61.9% of patients suffering from rUTI exhibited some degree of depression at baseline (Day 0). Alternative oral non-antimicrobial prophylactic treatment for rUTI [Escherichia coli lyophilized bacterial lysate (OM-89)] was administered to 94.4% of patients (1 capsule a day for 90 days), followed by a 3-month treatment-free period. At the end of the study (Day 180), the mean number of UTI decreased by 59.3% (P ≤ 0.0001), the total HAD score decreased by 32.1% (P ≤ 0.0001), and the mean Leicester score decreased by 44.0% (P ≤ 0.0001) from baseline. There was a correlation trend between the reduction in the numbers of UTI at the end of the study compared to the 6 months prior to study entry and the reduction in the anxiety, depression, total HAD scores, activity, feeling, and total Leicester scores registered from Day 0 to Day 180, suggesting a lessening of emotional problems, and social and functional handicaps with decreasing UTI incidence.
conclusionsThis study showed that rUTI had a negative impact on patients' QoL and that effective alternative prophylaxis significantly improved their QoL.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.