Evidence map›Paper›PMID 25519003›Full record

ArticleEuropean journal of nutrition2016

Dehydration affects cardiovascular nitric oxide synthases and caveolins in growing rats.

Vanina A Netti, Agustina N Iovane, Mariana C Vatrella, Natalia D Magnani, Pablo A Evelson, Elsa Zotta, Andrea L Fellet, Ana María Balaszczuk

Abstract read
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In one paragraph

Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. The Japanese Society of Hypertension Practical Consensus Guidelines for Seasonal Blood Pressure Management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Vanina A NettiCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, IQUIMEFA-CONICET, Junín 956, C1113AAD, Ciudad Autónoma De Buenos Aires, Argentina. vnetti@conicet.gov.ar.
Agustina N IovaneCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, IQUIMEFA-CONICET, Junín 956, C1113AAD, Ciudad Autónoma De Buenos Aires, Argentina.
Mariana C VatrellaCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, IQUIMEFA-CONICET, Junín 956, C1113AAD, Ciudad Autónoma De Buenos Aires, Argentina.
Natalia D MagnaniCátedra de Química General e Inorgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, C1113AAD, Ciudad Autónoma De Buenos Aires, Argentina.
Pablo A EvelsonCátedra de Química General e Inorgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, C1113AAD, Ciudad Autónoma De Buenos Aires, Argentina.
Elsa ZottaLaboratorio de Fisiopatogenia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, C1113AAD, Ciudad Autónoma De Buenos Aires, Argentina.
Andrea L FelletCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, IQUIMEFA-CONICET, Junín 956, C1113AAD, Ciudad Autónoma De Buenos Aires, Argentina.
Ana María BalaszczukCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, IQUIMEFA-CONICET, Junín 956, C1113AAD, Ciudad Autónoma De Buenos Aires, Argentina.
University of Buenos Aires · ARInstituto de Química y Fisicoquímica Biológicas · ARConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDuring the postnatal stage, cardiovascular nitric oxide (NO) system and caveolins (cav) may be regulated differentially in response to hypovolemic state induced by water restriction. Our aim was to examine the effects of water restriction on NO synthases (NOS) and cav in the atria, ventricle and aorta of growing rats.

methodsMale Sprague-Dawley rats aged 25 and 50 days were divided into (n = 15): WR: water restriction 3 days; WAL: water ad libitum 3 days. Systolic blood pressure, NOS activity and NOS/cav protein levels were measured.

resultsDehydration induced a larger increase in SBP in WR25 group. Ventricular NOS activity, endothelial NOS (eNOS) and neuronal isoform (nNOS) of WR25 pups were increased, and both cav were decreased. In the WR50 group, NOS activity remained unchanged. In the atria, NOS activity, eNOS and nNOS decreased in WR25 associated with increased cav-1; in the WR50 group, NOS activity was increased without changes in NOS isoforms. In the aorta of WR25, NOS activity and inducible NOS (iNOS) were decreased; NOS activity was unchanged in WR50, despite the decreased levels of eNOS and increased iNOS, cav-1 and cav-3.

conclusionsNO system adjustments in cardiovascular system under osmotic stress in vivo depend on postnatal age, being eNOS and nNOS, the isoforms that determine NOS activity in cardiac tissue in 25-day-old pups. Changes in cav abundance during hypovolemic state may contribute to age-related NO production.

Indexed as

DehydrationAnimalsBlood PressureCardiovascular SystemCaveolin 1Caveolin 3EndotheliumHeart AtriaHeart VentriclesHemodynamicsHypovolemiaMaleNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IINitric Oxide Synthase Type IIICav1 protein, ratCav3 protein, ratCaveolin 1Caveolin 3Nitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IINitric Oxide Synthase Type IIINos1 protein, ratNos2 protein, ratNos3 protein, ratThiobarbituric Acid Reactive SubstancesCardiovascular systemCaveolinsNitric oxidePostnatal growthWater restriction

Identifiers

PMID25519003
OpenAlexW2011677468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.