ArticleVirulence2015
Lactoylglutathione lyase, a critical enzyme in methylglyoxal detoxification, contributes to survival of Salmonella in the nutrient rich environment.
Article in Virulence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Neuroprotective effects of cell-free supernatant from Pediococcus pentosaceus TAP041 against glycation- and inflammation-associated stress responses.Applied microbiology and biotechnology · 2026Article
- Analysis of proteins and peptides to investigate the molecular signatures of a conventional antidiabetic herb, Boerhavia procumbens Banks ex Roxb. (Nyctaginaceae).Scientific reports · 2025Article
- Paracoccus sp. PS1: a novel probiotic strain for the mitigation of cardiometabolic risk factors TMA, TMAO, and methylglyoxal.Archives of microbiology · 2025Article
- Transcriptome Analysis Reveals the Key Genes and Pathways for Growth, Ion Transport, and Oxidative Stress in Post-Larval Black Tiger Shrimp (Penaeus monodon) Under Acute Low Salt Stress.Marine biotechnology (New York, N.Y.) · 2025Article
- Eco-Evolutionary Drivers of Vibrio parahaemolyticus Sequence Type 3 Expansion: Retrospective Machine Learning Approach.JMIR bioinformatics and biotechnology · 2024Article
- Evolutionary dynamics of the successful expansion of pandemic Vibrio parahaemolyticus ST3 in Latin America.Nature communications · 2024Article
- Proteomic Profiling ofInternational journal of molecular sciences · 2024Article
- Omics-based analysis ofMicrobiome research reports · 2024Article
- Glyoxalase I is a novel target for the prevention of metabolic derangement.Pharmacology & therapeutics · 2023Review
- The methylglyoxal pathway is a sink for glutathione in Salmonella experiencing oxidative stress.PLoS pathogens · 2023Article
- A Genetic Engineering Toolbox for the Lignocellulolytic Anaerobic Gut FungusACS synthetic biology · 2023Article
- Adaptation of Proteome and Metabolism in Different Haplotypes ofMicroorganisms · 2023Article
- Proteomics Profiling Reveals Regulation of Immune Response to Salmonella enterica Serovar Typhimurium Infection in Mice.Infection and immunity · 2023Article
- Dissemination of Extended-Spectrum-β-Lactamase-ProducingAntimicrobial agents and chemotherapy · 2021Article
- Arginine glycosylation enhances methylglyoxal detoxification.Scientific reports · 2021Article
- Phylogenomic analysis of Clostridioides difficile ribotype 106 strains reveals novel genetic islands and emergent phenotypes.Scientific reports · 2020Article
- Review
- Al-induced proteomics changes in tomato plants over-expressing a glyoxalase I gene.Horticulture research · 2020Article
- Glyoxalase 1 gene improves the antistress capacity and reduces the immune inflammatory response.BMC genetics · 2019Article
- GLYI4 Plays A Role in Methylglyoxal Detoxification and Jasmonate-Mediated Stress Responses inBiomolecules · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glyoxalase I which is synonymously known as lactoylglutathione lyase is a critical enzyme in methylglyoxal (MG) detoxification. We assessed the STM3117 encoded lactoylglutathione lyase (Lgl) of Salmonella Typhimurium, which is known to function as a virulence factor, due in part to its ability to detoxify methylglyoxal. We found that STM3117 encoded Lgl isomerises the hemithioacetal adduct of MG and glutathione (GSH) into S-lactoylglutathione. Lgl was observed to be an outer membrane bound protein with maximum expression at the exponential growth phase. The deletion mutant of S. Typhimurium (Δlgl) exhibited a notable growth inhibition coupled with oxidative DNA damage and membrane disruptions, in accordance with the growth arrest phenomenon associated with typical glyoxalase I deletion. However, growth in glucose minimal medium did not result in any inhibition. Endogenous expression of recombinant Lgl in serovar Typhi led to an increased resistance and growth in presence of external MG. Being a metalloprotein, Lgl was found to get activated maximally by Co(2+) ion followed by Ni(2+), while Zn(2+) did not activate the enzyme and this could be attributed to the geometry of the particular protein-metal complex attained in the catalytically active state. Our results offer an insight on the pivotal role of the virulence associated and horizontally acquired STM3117 gene in non-typhoidal serovars with direct correlation of its activity in lending survival advantage to Salmonella spp.
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