ArticleNature communications2014
Cell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- InOpen veterinary journal · 2025Article
- Unraveling astrocyte behavior in the space brain: Radiation response of primary astrocytes.Frontiers in public health · 2023Article
- Radiation resistance of normal human astrocytes: the role of non-homologous end joining DNA repair activity.Journal of radiation research · 2019Article
- Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery.Neuropharmacology · 2018Review
- Treatment-associatedOncotarget · 2018Article
- Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury.Oxidative medicine and cellular longevity · 2018Review
- Increase in the radioresistance of normal skin fibroblasts but not tumor cells by mechanical injury.Cell death & disease · 2017Article
- Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model.Neuro-oncology · 2016Article
- Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders.Genomics, proteomics & bioinformatics · 2016Review
- Mutational Analysis of Ionizing Radiation Induced Neoplasms.Cell reports · 2015Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
The misrepair of DNA double-strand breaks in close spatial proximity within the nucleus can result in chromosomal rearrangements that are important in the pathogenesis of haematopoietic and solid malignancies. It is unknown why certain epigenetic states, such as those found in stem or progenitor cells, appear to facilitate neoplastic transformation. Here we show that altering the transcriptional state of human astrocytes alters patterns of DNA damage repair from ionizing radiation at a gene locus-specific and genome-wide level. Astrocytes induced into a reactive state exhibit increased DNA repair, compared with non-reactive cells, in actively transcribed chromatin after irradiation. In mapping these repair sites, we identify misrepair events and repair hotspots that are unique to each state. The precise characterization of genomic regions susceptible to mutation in specific transcriptional states provides new opportunities for addressing clonal evolution in solid cancers, in particular those where double-strand break induction is a cornerstone of clinical intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.