ArticleOrganic letters2015
A biomimetic strategy to access the silybins: total synthesis of (-)-isosilybin A.
Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Catalytic enantioselective synthesis of tetrasubstituted chromanonesChemical science · 2020Article
- Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis.Chemical science · 2019Article
- Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins.Beilstein journal of organic chemistry · 2016Article
- Pyranone natural products as inspirations for catalytic reaction discovery and development.Accounts of chemical research · 2015Article
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Authors and funding
3 authors.
Funding
Abstract
We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the preparation of the entire isomeric family of silybin natural products.
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