ArticleMolecules (Basel, Switzerland)2014
Antiprotozoal activity against Entamoeba histolytica of plants used in northeast Mexican traditional medicine. Bioactive compounds from Lippia graveolens and Ruta chalepensis.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Antiamoeba and Antitrypanosoma Activity of the MexicanPathogens (Basel, Switzerland) · 2026Article
- Cytotoxic and Antimicrobial Activity of theMolecules (Basel, Switzerland) · 2025Review
- Antiparasitic Activity of Chalepensin and Graveoline Isolated fromPathogens (Basel, Switzerland) · 2025Article
- Antioxidant and Antibacterial Activity of Mexican Oregano Essential Oil, Extracted from Plants Occurring Naturally in Semiarid Areas and Cultivated in the Field and Greenhouse in Northern Mexico.Molecules (Basel, Switzerland) · 2023Article
- Cytotoxic, Anti-Hemolytic, and Antioxidant Activities ofPlants (Basel, Switzerland) · 2023Article
- Hunting Bioactive Molecules from theMolecules (Basel, Switzerland) · 2021Review
- Review
- Furanocoumarins fromMolecules (Basel, Switzerland) · 2021Article
- Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential.Molecules (Basel, Switzerland) · 2021Review
- Antiprotozoal Activity againstMolecules (Basel, Switzerland) · 2020Article
- Development of a Novel Ex-vivo 3D Model to Screen Amoebicidal Activity on Infected Tissue.Scientific reports · 2019Article
- Natural products as reservoirs of novel therapeutic agents.EXCLI journal · 2018Review
- Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri.PLoS neglected tropical diseases · 2017Article
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7 authors.
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Abstract
Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality is becoming a major public health problem worldwide, especially in developing countries. Because of the side-effects and the resistance that pathogenic protozoa build against the standard antiparasitic drugs, e.g., metronidazole, much recent attention has been paid to plants used in traditional medicine around the world in order to find new antiprotozoal agents. We collected 32 plants used in Northeast Mexican traditional medicine and the methanolic extracts of these species were screened for antiprotozoal activity against E. histolytica trophozoites using in vitro tests. Only 18 extracts showed a significant inhibiting activity and among them six plant extracts showed more than 80% growth inhibition against E. histolytica at a concentration of 150 µg/mL and the IC50 values of these extracts were determined. Lippia graveolens Kunth and Ruta chalepensis Pers. showed the more significant antiprotozoal activity (91.54% and 90.50% growth inhibition at a concentration of 150 µg/mL with IC50 values of 59.14 and 60.07 µg/mL, respectively). Bioassay-guided fractionation of the methanolic extracts from these two plants afforded carvacrol (1) and chalepensin (2), respectively, as bioactive compounds with antiprotozoal activity.
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