ReviewCurrent opinion in infectious diseases2015
Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection.
Review in Current opinion in infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- More than an infection: the ecological puzzle of recurrent urinary tract infections.Frontiers in cellular and infection microbiology · 2026Review
- Risk factors for positive urine culture and antimicrobial resistance in suspected UTI after flexible ureteroscopic lithotripsy.Frontiers in surgery · 2026Article
- CAUTIon - not all UTIs are the same.Nature reviews. Urology · 2025Review
- Urinary Tract Infections Caused by UropathogenicInternational journal of molecular sciences · 2023Review
- Article
- Effect of bovine lactoferrin on recurrent urinary tract infections: in vitro and in vivo evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Phenotypic and genotypic characteristics ofFrontiers in public health · 2023Article
- A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence.Nucleic acids research · 2022Article
- What is the Cause of Recurrent Urinary Tract Infection? Contemporary Microscopic Concepts of Pathophysiology.International neurourology journal · 2021Article
- Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women.Life science alliance · 2021Article
- Sex effects in pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2021Review
- Circulating mucosal-associated invariant T cells in subjects with recurrent urinary tract infections are functionally impaired.Immunity, inflammation and disease · 2020Article
- Effect and Analysis of Bacterial Lysates for the Treatment of Recurrent Urinary Tract Infections in Adults.Pathogens (Basel, Switzerland) · 2020Article
- Amniotic Membrane Preparation Crucially Affects Its Broad-Spectrum Activity Against Uropathogenic Bacteria.Frontiers in microbiology · 2020Article
- Article
- Propolis potentiates the effect of cranberry (Vaccinium macrocarpon) against the virulence of uropathogenic Escherichia coli.Scientific reports · 2018Article
- Article
- Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis.Disease models & mechanisms · 2017Article
- Antibiotic Resistance in Urinary Isolates ofMateria socio-medica · 2016Article
- Urinary Tract Infection: Pathogenesis and Outlook.Trends in molecular medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewRecurrent urinary tract infection (rUTI) is a serious clinical problem, yet effective therapeutic options are limited, especially against multidrug-resistant uropathogens. In this review, we explore the development of a clinically relevant model of rUTI in previously infected mice and review recent developments in bladder innate immunity that may affect susceptibility to rUTI. RECENT
findingsChronic bladder inflammation during prolonged bacterial cystitis in mice causes bladder mucosal remodelling that sensitizes the host to rUTI. Although constitutive defenses help prevent bacterial colonization of the urinary bladder, once infection occurs, induced cytokine and myeloid cell responses predominate and the balance of immune cell defense and bladder immunopathology is critical for determining disease outcome, in both naïve and experienced mice. In particular, the maintenance of the epithelial barrier appears to be essential for preventing severe infection. SUMMARY: The innate immune response plays a key role in determining susceptibility to rUTI. Future studies should be directed towards understanding how the innate immune response changes as a result of bladder mucosal remodelling in previously infected mice, and validating these findings in human clinical specimens. New therapeutics targeting the immune response should selectively target the induced innate responses that cause bladder immunopathology, while leaving protective defenses intact.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.