ArticleBiophysical journal2014
Nonlinear compliance modulates dynamic bronchoconstriction in a multiscale airway model.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- A Quick Method to Assess Airway Distensibility in Mice.Annals of biomedical engineering · 2024Article
- A multiscale sliding filament model of lymphatic muscle pumping.Biomechanics and modeling in mechanobiology · 2021Article
- Article
- Reduced biomechanical models for precision-cut lung-slice stretching experiments.Journal of mathematical biology · 2021Article
- Airway smooth muscle adapting in dynamic conditions is refractory to the bronchodilator effect of a deep inspiration.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Extracellular matrix stiffness regulates human airway smooth muscle contraction by altering the cell-cell coupling.Scientific reports · 2019Article
- Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling.Biomechanics and modeling in mechanobiology · 2018Article
- Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions.Biophysical journal · 2018Article
- A Distribution-Moment Approximation for Coupled Dynamics of the Airway Wall and Airway Smooth Muscle.Biophysical journal · 2018Article
- Multiscale modeling methods in biomechanics.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Airway Bistability Is Modulated by Smooth Muscle Dynamics and Length-Tension Characteristics.Biophysical journal · 2016Article
- Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.Frontiers in physiology · 2016Article
- Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways?Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Airway and Extracellular Matrix Mechanics in COPD.Frontiers in physiology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The role of breathing and deep inspirations (DI) in modulating airway hyperresponsiveness remains poorly understood. In particular, DIs are potent bronchodilators of constricted airways in nonasthmatic subjects but not in asthmatic subjects. Additionally, length fluctuations (mimicking DIs) have been shown to reduce mean contractile force when applied to airway smooth muscle (ASM) cells and tissue strips. However, these observations are not recapitulated on application of transmural pressure (PTM) oscillations (that mimic tidal breathing and DIs) in isolated intact airways. To shed light on this paradox, we have developed a biomechanical model of the intact airway, accounting for strain-stiffening due to collagen recruitment (a large component of the extracellular matrix (ECM)), and dynamic actomyosin-driven force generation by ASM cells. In agreement with intact airway studies, our model shows that PTM fluctuations at particular mean transmural pressures can lead to only limited bronchodilation. However, our model predicts that moving the airway to a more compliant point on the static pressure-radius relationship (which may involve reducing mean PTM), before applying pressure fluctuations, can generate greater bronchodilation. This difference arises from competition between passive strain-stiffening of ECM and force generation by ASM yielding a highly nonlinear relationship between effective airway stiffness and PTM, which is modified by the presence of contractile agonist. Effectively, the airway at its most compliant may allow for greater strain to be transmitted to subcellular contractile machinery. The model predictions lead us to hypothesize that the maximum possible bronchodilation of an airway depends on its static compliance at the PTM about which the fluctuations are applied. We suggest the design of additional experimental protocols to test this hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.