ArticleProceedings of the National Academy of Sciences of the United States of America2014
In vivo anticancer activity of rhomboidal Pt(II) metallacycles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 104 citations in OpenAlex.
- Architecting NIR-II metal supramolecular dyes-illuminating the path to precision medicine.Chemical science · 2026Review
- Self-Assembled Iron(III) Coordination Cage as an MRI-Active Carrier for a Gold(I) Drug.Bioconjugate chemistry · 2024Article
- Dual-Emissive Rectangular Supramolecular Pt(II)-Molecules (Basel, Switzerland) · 2023Article
- Metal-Coordinated Supramolecular Self-Assemblies for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Supramolecular coordination complexes as diagnostic and therapeutic agents.Current opinion in chemical biology · 2021Review
- β-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Over one century after discovery: pyrylium salt chemistry emerging as a powerful approach for the construction of complex macrocycles and metallo-supramolecules.Chemical science · 2020Review
- Biomedical Applications of Metal Organic Polygons and Polyhedra (MOPs).Coordination chemistry reviews · 2020Article
- Supramolecular Metallacycles and Their Binding of Fullerenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Porphyrin-Based Organoplatinum(II) Metallacycles With Enhanced Photooxidization Reactivity.Frontiers in chemistry · 2020Article
- Biomedically Relevant Self-Assembled Metallacycles and Metallacages.Journal of the American Chemical Society · 2019Review
- Melanin-dot-mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(ii) metallacycle for efficient cancer imaging and therapy.Chemical science · 2019Article
- Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtAngewandte Chemie (International ed. in English) · 2019Article
- Modular Metal-Organic Polyhedra Superassembly: From Molecular-Level Design to Targeted Drug Delivery.Advanced materials (Deerfield Beach, Fla.) · 2019Article
- Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nanoparticles of Metal-Organic Cages Overcoming Drug Resistance in Ovarian Cancer.Frontiers in chemistry · 2019Article
- Recent Developments of Supramolecular Metal-based Structures for Applications in Cancer Therapy and Imaging.Theranostics · 2019Review
- Diamondoid Supramolecular Coordination Frameworks from Discrete Adamantanoid Platinum(II) Cages.Journal of the American Chemical Society · 2018Article
- Anticancer Activity and Cisplatin Binding Ability ofFrontiers in chemistry · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The development of novel antitumor agents that have high efficacy in suppressing tumor growth, have low toxicity to nontumor tissues, and exhibit rapid localization in the targeted tumor sites is an ongoing avenue of research at the interface of chemistry, cancer biology, and pharmacology. Supramolecular metal-based coordination complexes (SCCs) have well-defined shapes and geometries, and upon their internalization, SCCs could affect multiple oncogenic signaling pathways in cells and tissues. We investigated the uptake, intracellular localization, and antitumor activity of two rhomboidal Pt(II)-based SCCs. Laser-scanning confocal microscopy in A549 and HeLa cells was used to determine the uptake and localization of the assemblies within cells and their effect on tumor growth was investigated in mouse s.c. tumor xenograft models. The SCCs are soluble in cell culture media within the entire range of studied concentrations (1 nM-5 µM), are nontoxic, and showed efficacy in reducing the rate of tumor growth in s.c. mouse tumor xenografts. These properties reveal the potential of Pt(II)-based SCCs for future biomedical applications as therapeutic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.