ArticleDevelopment (Cambridge, England)2015
Dose-dependent nuclear β-catenin response segregates endomesoderm along the sea star primary axis.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Reconstructing the evolutionary origin of β-catenin recognition in the Wnt destruction complex.Molecular biology and evolution · 2026Article
- A stage and anatomy ontology for embryogenesis in indirect-developing echinoderms.Development (Cambridge, England) · 2026Article
- Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis.Nature communications · 2025Article
- β-catenin-driven endomesoderm specification is a Bilateria-specific novelty.Nature communications · 2025Article
- Recycling of Uridylated mRNAs in Starfish Embryos.Biomolecules · 2024Article
- Spatiotemporal requirements of nuclear β-catenin define early sea urchin embryogenesis.PLoS biology · 2024Article
- Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective.International journal of molecular sciences · 2024Review
- Molecular mechanisms of tubulogenesis revealed in the sea star hydro-vascular organ.Nature communications · 2023Article
- Gene regulatory divergence amongst echinoderms underlies appearance of pigment cells in sea urchin development.Developmental biology · 2023Article
- Sea anemone Frizzled receptors play partially redundant roles in oral-aboral axis patterning.Development (Cambridge, England) · 2022Article
- Live imaging of echinoderm embryos to illuminate evo-devo.Frontiers in cell and developmental biology · 2022Article
- Polarized Dishevelled dissolution and reassembly drives embryonic axis specification in sea star oocytes.Current biology : CB · 2021Article
- Review
- Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning.Nature communications · 2021Article
- Systematic comparison of sea urchin and sea star developmental gene regulatory networks explains how novelty is incorporated in early development.Nature communications · 2020Article
- Analysis of sea star larval regeneration reveals conserved processes of whole-body regeneration across the metazoa.BMC biology · 2019Article
- Conserved regulatory state expression controlled by divergent developmental gene regulatory networks in echinoids.Development (Cambridge, England) · 2018Article
- Cas9-mediated excision ofDevelopment (Cambridge, England) · 2017Article
- Genome-wide use of high- and low-affinity Tbrain transcription factor binding sites during echinoderm development.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
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4 authors.
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Abstract
In many invertebrates, the nuclearization of β-catenin at one pole of the embryo initiates endomesoderm specification. An intriguing possibility is that a gradient of nuclear β-catenin (nβ-catenin), similar to that operating in vertebrate neural tube patterning, functions to distinguish cell fates in invertebrates. To test this hypothesis, we determined the function of nβ-catenin during the early development of the sea star, which undergoes a basal deuterostomal mode of embryogenesis. We show that low levels of nβ-catenin activity initiate bra, which is expressed in the future posterior endoderm-fated territory; intermediate levels are required for expression of foxa and gata4/5/6, which are later restricted to the endoderm; and activation of ets1 and erg in the mesoderm-fated territory requires the highest nβ-catenin activity. Transcription factors acting downstream of high nβ-catenin segregate the endoderm/mesoderm boundary, which is further reinforced by Delta/Notch signaling. Significantly, therefore, in sea stars, endomesoderm segregation arises through transcriptional responses to levels of nβ-catenin activity. Here, we describe the first empirical evidence of a dose-dependent response to a dynamic spatiotemporal nβ-catenin activity that patterns cell fates along the primary axis in an invertebrate.
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