ArticleImmunity & ageing : I & A2014
The 21st century epidemic: infections as inductors of neuro-degeneration associated with Alzheimer's Disease.
Article in Immunity & ageing : I & A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Meta-Analysis of Gene Expression Changes in the Blood of Patients with Mild Cognitive Impairment and Alzheimer's Disease Dementia.International journal of molecular sciences · 2019Pooled it
- Interprofessional education in the care of people diagnosed with dementia and their carers: a systematic review.BMJ open · 2016Pooled it
- Broken but not beaten: Challenge of reducing the amyloids pathogenicity by degradation.Journal of advanced research · 2025Review
- Exploiting the Unique Biology ofAstrobiology · 2024Article
- Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study.PLoS neglected tropical diseases · 2023Article
- Amyloid fibrils degradation: the pathway to recovery or aggravation of the disease?Frontiers in molecular biosciences · 2023Article
- Does Dementia Have a Microbial Cause?NeuroSci · 2022Review
- Clinical outcomes of COVID-19 infection among patients with Alzheimer's disease or mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Alzheimer's disease is an inherent, natural part of human brain aging: an integrated perspective.Free neuropathology · 2022Article
- Review
- Potential Virus Involvement in Alzheimer's Disease: Results from a Phase IIa Trial Evaluating Apovir, an Antiviral Drug Combination.Journal of Alzheimer's disease reports · 2021Article
- The Possibility of an Infectious Etiology of Alzheimer Disease.Molecular neurobiology · 2019Review
- Transcriptomic and Network Analysis Highlight the Association of Diabetes at Different Stages of Alzheimer's Disease.Frontiers in neuroscience · 2019Article
- Review
- Evidence of Human Parvovirus B19 Infection in the Post-Mortem Brain Tissue of the Elderly.Viruses · 2018Article
- The Infectious Etiology of Alzheimer's Disease.Current neuropharmacology · 2017Review
- Persistent infections, immune-senescence and Alzheimer's disease.Oncoscience · 2016Article
- Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders.International journal of molecular sciences · 2015Review
- Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2015Review
- Alzheimer's disease and infections, where we stand and where we go.Immunity & ageing : I & A · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a complex disease resulting in neurodegeneration and cognitive impairment. Investigations on environmental factors implicated in AD are scarce and the etiology of the disease remains up to now obscure. The disease's pathogenesis may be multi-factorial and different etiological factors may converge during aging and induce an activation of brain microglia and macrophages. This microglia priming will result in chronic neuro-inflammation under chronic antigen activation. Infective agents may prime and drive iper-activation of microglia and be partially responsible of the induction of brain inflammation and decline of cognitive performances. Age-associated immune dis-functions induced by chronic sub-clinical infections appear to substantially contribute to the appearance of neuro-inflammation in the elderly. Individual predisposition to less efficient immune responses is another relevant factor contributing to impaired regulation of inflammatory responses and accelerated cognitive decline. Life-long virus infection may play a pivotal role in activating peripheral and central inflammatory responses and in turn contributing to increased cognitive impairment in preclinical and clinical AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.