Evidence map›Paper›PMID 25516688›Full record

ArticleWorld journal of gastroenterology2014

Diagnostically untypable hepatitis C virus variants: it is time to resolve the problem.

Muhammad Sohail Afzal, Muhammad Yousaf Khan, Muhammad Ammar, Sadia Anjum, Najm Us Sahar Sadaf Zaidi

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Update on hepatitis B and C virus diagnosis.World journal of virology · 2015
    Review
  8. Association of genotypes with viral load and biochemical markers in HCV-infected Sindhi patients.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
    Article
  9. Recent HCV genotype changing pattern in the Khyber Pakhtunkhwa province of Pakistan; is it pointing out a forthcoming problem?The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad Sohail AfzalMuhammad Sohail Afzal, Sadia Anjum, Najm us Sahar Sadaf Zaidi, Atta Ur Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad 44000, Pakistan.
Muhammad Yousaf KhanMuhammad Sohail Afzal, Sadia Anjum, Najm us Sahar Sadaf Zaidi, Atta Ur Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad 44000, Pakistan.
Muhammad AmmarMuhammad Sohail Afzal, Sadia Anjum, Najm us Sahar Sadaf Zaidi, Atta Ur Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad 44000, Pakistan.
Sadia AnjumMuhammad Sohail Afzal, Sadia Anjum, Najm us Sahar Sadaf Zaidi, Atta Ur Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad 44000, Pakistan.
Najm Us Sahar Sadaf ZaidiMuhammad Sohail Afzal, Sadia Anjum, Najm us Sahar Sadaf Zaidi, Atta Ur Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad 44000, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pakistan is a low income country with more than 10 million hepatitis C virus (HCV) infections and the burden is on continuous raise. Accurate viral genotyping is very critical for proper treatment of the infected individuals as the sustained virological response of the standard antiviral interferon therapy is genotype dependent. We observed at our diagnostic center that 15.6% of HCV patient's samples were not genotype-able by using Ohno et al method. The genotyped samples showed that 3a (68.3%) is the major prevalent genotype in Pakistan followed by 2a (10.3%), 3b (2.6%), 1b (1.5%), 2b (1.2%) and 1a (0.5%). Presence of large number of untypable HCV variants in the current study highlights an important issue of health care setup in Pakistan. Untypable HCV cases create difficulties in treatment of these patients. The problem of routine diagnostics setup of Pakistan should be addressed on priority basis to facilitate the medical professionals in patient's treatment and to help in achieving the maximum sustained virological response.

Indexed as

Molecular Diagnostic TechniquesAntiviral AgentsDeveloping CountriesGenotypeHepacivirusHepatitis CHumansPakistanPredictive Value of TestsPrevalencePrognosisReproducibility of ResultsAntiviral AgentsAntiviral interferon therapyDiagnosticsGenotypesHepatitis C virusPakistanUntypable variants

Identifiers

PMID25516688
PMCPMC4265635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.