ArticleWorld journal of gastroenterology2014
Cytokine production in patients with cirrhosis and TLR4 polymorphisms.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of mental disorders on clinical outcomes of physical diseases: an umbrella review assessing population attributable fraction and generalized impact fraction.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites.World journal of hepatology · 2018Article
- Molecular mechanisms of HBeAg in persistent HBV infection.Hepatology international · 2017Article
- What we know: the inflammatory basis of hepatic encephalopathy.Metabolic brain disease · 2016Review
- Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications.World journal of hepatology · 2015Article
- Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats.World journal of gastroenterology · 2015Article
- Lack of Association between Polymorphisms of the TLR4 Gene and Infection with the Hepatitis B and C Viruses.Mediators of inflammation · 2015Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.
methodsThe study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms, and 10 wild-type patients matched for age, sex and degree of liver failure. TLR4 polymorphisms were determined by sequence-based genotyping. Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide (LPS) and lipoteichoic acid (LTA) stimulation.
resultsPatients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients (78% vs 20%, P = 0.02). Spontaneous production of interleukin (IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients [IL-6: 888.7 (172.0-2119.3) pg/mL vs 5540.4 (1159.2-26053.9) pg/mL, P < 0.001; IL-10: 28.7 (6.5-177.1) pg/mL vs 117.8 (6.5-318.1) pg/mL, P = 0.02]. However, the production of tumor necrosis factor-α, IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.
conclusionTLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients, suggesting that they play a role in the development of cirrhosis complications.
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