ArticleWorld journal of gastroenterology2014
Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Bioartificial liver support systems for acute liver failure: A systematic review and meta-analysis of the clinical and preclinical literature.World journal of gastroenterology · 2019Pooled it
- A novel, simplified, and reproducible porcine model of acute ischemic liver failure with portal vein preservation.Experimental animals · 2022Article
- Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury.International journal of molecular sciences · 2021Article
- Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure.Nano-micro letters · 2020Review
- End-stage liver failure: filling the treatment gap at the intensive care unit.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2020Review
- Novel sericin-based hepatocyte serum-free medium and sericin's effect on hepatocyte transcriptome.World journal of gastroenterology · 2018Article
- [Progress in hepatocyte status detection and its application in bioartificial liver support system].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018Review
- Artificial Liver and Renal Support System for Cynomolgus Monkeys with Surgery-Induced Acute Renal Failure: A Preclinical Study.BioMed research international · 2018Article
- N,N-dimethylformamide-induced acute hepatic failure: A case report and literature review.Experimental and therapeutic medicine · 2017Article
- Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure.World journal of gastroenterology · 2017Article
- Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes.Cell research · 2016Article
- Establishment of a Novel Simplified Surgical Model of Acute Liver Failure in the Cynomolgus Monkey.BioMed research international · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate a hybrid bioartificial liver support system (HBALSS) in cynomolgus monkeys with acute liver failure.
methodsTo establish a model of acute liver failure, 0.3 g/kg of D-galactosamine was injected intravenously into cynomolgus monkeys. Chinese human liver cells were introduced into a perfusion bioreactor to carry out hybrid bioartificial liver support treatment. Forty-eight hours after the injection, one group of cynomolgus monkeys received HBALSS care, and a second experimental group received no treatment. Clinical manifestations of all animals, survival time, liver and kidney functions and serum biochemistry changes were recorded. Simultaneous detection of the number, viability and function of hepatocytes in the hybrid bioartificial liver were also performed.
resultsForty-eight hours after the injection of D-galactosamine, serum biochemistry levels were significantly increased, whereas albumin levels and the Fischer index were significantly reduced compared to baseline (all Ps < 0.05). Of the ten monkeys in the HBALSS treatment group, five survived, with an average duration of survival of 128 ± 3 h. All cynomolgus monkeys in the control group died, with a duration of survival of 112 ± 2 h. Survival time was significantly longer with HBALSS treatment (P < 0.05). Moreover, the number, viability and function of hepatocytes were maintained at a high level with HBALSS.
conclusionThe novel hybrid bioartificial liver plays a significant role in liver support by significantly reducing serum biochemistry levels and extending animal survival time.
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