Evidence map›Paper›PMID 25516636›Full record

ReviewJournal of toxicologic pathology2014

Nonproliferative and proliferative lesions of the rat and mouse female reproductive system.

Darlene Dixon, Roger Alison, Ute Bach, Karyn Colman, George L Foley, Johannes H Harleman, Richard Haworth, Ronald Herbert, Anke Heuser, Gerald Long and 6 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of toxicologic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
  2. Article
  3. Delta-like Ligand 3-DirectedJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Article
  5. Exploring the 89Zr/177Lu Theranostic Pairing with an Extracellular Matrix-Targeted Radiopharmaceutical against Triple-Negative Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Brain-Specific Gata4 Downregulation in Greywick Female Mice Models the Metabolic Subtype of Polycystic Ovary Syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Comparative ovarian morphophysiology ofAnimal reproduction · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 5 countries.

Darlene DixonNational Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina, USA.
Roger AlisonRoger Alison Ltd, Pathology Consultancy Services, Caerfyrddin Fach, Cilcennin, Lampeter, SA48 8RN, United Kingdom.
Ute BachBayer Pharma AG, Wuppertal, Germany.
Karyn ColmanNovartis Institute for Biomedical Research, Novartis, East Hanover, New Jersey, USA.
George L FoleyAbbVie, Inc., North Chicago, Illinois, USA.
Johannes H HarlemanFresenius Kabi Deutschland GmbH, Bad Homburg, Germany.
Richard HaworthGlaxoSmithKline R&D, Park Road, Ware, Hertfordshire, SG12 ODP, United Kingdom.
Ronald HerbertNational Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina, USA.
Anke HeuserRoche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacher Strasse 124, 4070 Basel, Switzerland.
Gerald LongExperimental Pathology Laboratories, Indianapolis, Indiana, USA.
Michael MirskyPfizer Worldwide Research and Development, Groton, Connecticut, USA.
Karen ReganRegan Path/Tox Services, Ashland, Ohio, USA.
Eric Van EschInSight Pathology BV, Chopinlaan 6, Oss, The Netherlands.
F Russell WestwoodAstraZeneca, Macclesfield, Cheshire, United Kingdom (Retired).
Justin VidalGlaxoSmithKline, King of Prussia, Pennsylvania, USA.
Midori YoshidaNational Institute of Health Sciences, Tokyo, Japan.
National Institute of Environmental Health Sciences · USAbbVie (United States) · USAshland (United States) · USAstraZeneca (United Kingdom) · GBBayer (Germany) · DEExperimental Pathology Laboratories · USFresenius (Germany) · DEGlaxoSmithKline (United Kingdom) · GBNational Institute of Health Sciences · JPNovartis (United States) · USPfizer (United States) · USRoche (Switzerland) · CH

Funding

Pathobiology Of Uterine Leiomyomas (fibroids)ZIAES021196 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DIXON, DARLENE · 2009 to 2025
$31.7M
6 · The paper itself

Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the female reproductive tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. There is also a section on normal cyclical changes observed in the ovary, uterus, cervix and vagina to compare normal physiological changes with pathological lesions. A widely accepted and utilized international harmonization of nomenclature for female reproductive tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

Indexed as

cervixdiagnostic pathologyfemale reproductivenomenclatureovaryuterusvagina

Identifiers

PMID25516636
PMCPMC4253081
OpenAlexW2031148568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.