ArticleThe Plant cell2014
MicroRNA408 is critical for the HY5-SPL7 gene network that mediates the coordinated response to light and copper.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed.
- Synergistic regulation of abiotic stress adaptation by copper miRNAs miR398 and miR408 in melon.The Plant journal : for cell and molecular biology · 2026Article
- The CPK3-mediated cytosolic-nuclear translocation of bHLH107 recruits HY5 to regulate the CuJournal of advanced research · 2026Article
- Copper-sensitive OsSPL9 TF regulates expression of indica rice domestication-associated miRNAs and phenotypes.Communications biology · 2026Article
- POLARIS is a copper-binding peptide that interacts with ETR1 to negatively regulate ethylene signaling in Arabidopsis.Plant communications · 2025Article
- Molecular Evolution of Cu Transporters and Transcription Factors in Plant Response to Copper Stress.Plants (Basel, Switzerland) · 2025Review
- Decoding Long-Distance Communication Under Mineral Stress: Advances in Vascular Signalling and Molecular Tools for Plant Resilience.Plant, cell & environment · 2025Review
- Identification and Characterization of Copper-Responsive miRNAs and Their Target Genes in Jerusalem Artichoke.Plants (Basel, Switzerland) · 2025Article
- MicroRNA gatekeepers: Orchestrating rhizospheric dynamics.Journal of integrative plant biology · 2025Review
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling.Journal of experimental botany · 2025Review
- Deciphering the impact of microRNAs in plant biology: a review of computational insights and experimental validation.Molecular biology reports · 2025Review
- The microRNA408-plantacyanin module balances plant growth and drought resistance by regulating reactive oxygen species homeostasis in guard cells.The Plant cell · 2024Article
- Molecular Mechanisms of Plant Responses to Copper: From Deficiency to Excess.International journal of molecular sciences · 2024Review
- Switching action modes of miR408-5p mediates auxin signaling in rice.Nature communications · 2024Article
- Overexpression of lily MicroRNA156-resistantFrontiers in plant science · 2024Article
- The ncRNAs Involved in the Regulation of Abiotic Stress-Induced Anthocyanin Biosynthesis in Plants.Antioxidants (Basel, Switzerland) · 2023Review
- Genome-Wide Identification and Expression Analysis of the SBP-Box Gene Family in Loquat Fruit Development.Genes · 2023Article
- The miR408a-BBP-LAC3/CSD1 module regulates anthocyanin biosynthesis mediated by crosstalk between copper homeostasis and ROS homeostasis during light induction in Malus plants.Journal of advanced research · 2023Article
- microRNA408 and its encoded peptide regulate sulfur assimilation and arsenic stress response in Arabidopsis.Plant physiology · 2023Article
- Delineating the tissue-mediated drought stress governed tuning of conserved miR408 and its targets in rice.Functional & integrative genomics · 2023Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
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Abstract
Light and copper are important environmental determinants of plant growth and development. Despite the wealth of knowledge on both light and copper signaling, the molecular mechanisms that integrate the two pathways remain poorly understood. Here, we use Arabidopsis thaliana to demonstrate an interaction between SQUAMOSA PROMOTER BINDING PROTEIN-LIKE7 (SPL7) and ELONGATED HYPOCOTYL5 (HY5), which mediate copper and light signaling, respectively. Through whole-genome chromatin immunoprecipitation and RNA sequencing analyses, we elucidated the SPL7 regulon and compared it with that of HY5. We found that the two transcription factors coregulate many genes, including those involved in anthocyanin accumulation and photosynthesis. Moreover, SPL7 and HY5 act coordinately to transcriptionally regulate MIR408, which results in differential expression of microRNA408 (miR408) and its target genes in response to changing light and copper conditions. We demonstrate that this regulation is tied to copper allocation to the chloroplast and plastocyanin levels. Finally, we found that constitutively activated miR408 rescues the distinct developmental defects of the hy5, spl7, and hy5 spl7 mutants. These findings revealed the existence of crosstalk between light and copper, mediated by a HY5-SPL7 network. Furthermore, integration of transcriptional and posttranscriptional regulation is critical for governing proper metabolism and development in response to combined copper and light signaling.
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