ArticleMagnetic resonance in medicine2015
Multi-echo length and offset VARied saturation (MeLOVARS) method for improved CEST imaging.
Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Isolation of amide proton transfer effect and relayed nuclear Overhauser enhancement effect at -3.5ppm using CEST with double saturation powers.Magnetic resonance in medicine · 2023Article
- Radiofrequency labeling strategies in chemical exchange saturation transfer MRI.NMR in biomedicine · 2023Review
- A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging.International journal of molecular sciences · 2021Review
- Whole-brain amide CEST imaging at 3T with a steady-state radial MRI acquisition.Magnetic resonance in medicine · 2021Article
- Assessments of tumor metabolism with CEST MRI.NMR in biomedicine · 2019Review
- Differentiation of Myositis-Induced Models of Bacterial Infection and Inflammation with TTomography (Ann Arbor, Mich.) · 2019Article
- Machine learning improves classification of preclinical models of pancreatic cancer with chemical exchange saturation transfer MRI.Magnetic resonance in medicine · 2019Article
- Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF).Magnetic resonance in medicine · 2018Article
- Simultaneous pH-sensitive and oxygen-sensitive MRI of human gliomas at 3 T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging (CEST-SAGE-EPI).Magnetic resonance in medicine · 2018Article
- CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena.Magnetic resonance in medicine · 2018Review
- Chemical exchange saturation transfer fingerprinting for exchange rate quantification.Magnetic resonance in medicine · 2018Article
- Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum.NeuroImage · 2018Review
- Salicylic acid analogues as chemical exchange saturation transfer MRI contrast agents for the assessment of brain perfusion territory and blood-brain barrier opening after intra-arterial infusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Screening CEST contrast agents using ultrafast CEST imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Article
- Label-free CEST MRI Detection of Citicoline-Liposome Drug Delivery in Ischemic Stroke.Theranostics · 2016Article
- Recent Advances inEngineering (Beijing, China) · 2015Article
- Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells.Nature communications · 2015Article
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9 authors.
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Abstract
purposeThe aim of this study was to develop a technique for rapid collection of chemical exchange saturation transfer images with the saturation varied to modulate signal loss transfer and enhance contrast.
methodsMulti-echo Length and Offset VARied Saturation (MeLOVARS) divides the saturation pulse of length Tsat into N = 3-8 submodules, each consisting of a saturation pulse with length of Tsat /N (∼0.3-1 s), one or more low flip-angle gradient-echo readout(s) and a flip back pulse. This results in N readouts with increasing saturation time from Tsat /N to Tsat without extra scan time.
resultsFor phantoms, eight images with Tsat incremented every 0.5 s from 0.5-4 s were collected simultaneously using MeLOVARS, which allows rapid determination of exchange rates for agent protons. For live mice bearing glioblastomas, the Z-spectra for five different Tsat values from 0.5 to 2.5 s were acquired in a time normally used for one Tsat . With the additional Tsat -dependence information, LOVARS phase maps were produced with a more clearly defined tumor boundary and an estimated 4.3-fold enhanced contrast-to-noise ratio (CNR). We also show that enhancing CNR is achievable by simply averaging the collected images or transforming them using the principal component analysis.
conclusionsMeLOVARS enables collection of multiple saturation-time-weighted images without extra time, producing a LOVARS phase map with increased CNR.
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