Electrophysiological changes correlated with temperature increases induced by high-intensity focused ultrasound ablation.

Ziqi Wu, Ronald E Kumon, Jacob I Laughner, Igor R Efimov, Cheri X Deng

Abstract read

In one paragraph

Article in Ultrasound in medicine & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Ziqi WuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Ronald E KumonDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Jacob I LaughnerDepartment of Biomedical Engineering, Washington University at Saint Louis, MO, USA.

Igor R EfimovDepartment of Biomedical Engineering, Washington University at Saint Louis, MO, USA.

Cheri X DengDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: xdeng@umich.edu.

Funding

Advanced Ultrasound Ablation Therapy for Atrial FibrillationR01EB008999 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DENG, CHERI X · 2008 to 2012

$2.8M

EAPO CDC HHS R01 EP008999NIBIB NIH HHS R01 EB008999

6 · The paper itself

Abstract

To gain better understanding of the detailed mechanisms of high-intensity focused ultrasound (HIFU) ablation for cardiac arrhythmias, we investigated how the cellular electrophysiological (EP) changes were correlated with temperature increases and thermal dose (cumulative equivalent minutes [CEM43]) during HIFU application using Langendorff-perfused rabbit hearts. Employing voltage-sensitive dye di-4-ANEPPS, we measured the EP and temperature during HIFU using simultaneous optical mapping and infrared imaging. Both action potential amplitude (APA) and action potential duration at 50% repolarization (APD50) decreased with temperature increases, and APD50 was more thermally sensitive than APA. EP and tissue changes were irreversible when HIFU-induced temperature increased above 52.3 ± 1.4°C and log10(CEM43) above 2.16 ± 0.51 (n = 5), but were reversible when temperature was below 50.1 ± 0.8°C and log10(CEM43) below -0.9 ± 0.3 (n = 9). EP and temperature/thermal dose changes were spatially correlated with HIFU-induced tissue necrosis surrounded by a transition zone.

Indexed as

Hot TemperatureAnimalsArrhythmias, CardiacDisease Models, AnimalElectrophysiological PhenomenaHigh-Intensity Focused Ultrasound AblationRabbitsBioeffectsCellular electrophysiologyHigh-intensity focused ultrasoundInfrared imagingLangendorff-perfused rabbit heartsOptical mapping

Identifiers

PMID25516446

DOI10.1016/j.ultrasmedbio.2014.09.009

PMCPMC4297512

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.