ArticleJournal of the American Heart Association2014
Potential reduction of interstitial myocardial fibrosis with renal denervation.
Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Reductions of left ventricular mass and atrial size following renal denervation: a meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Pooled it
- Effects of sympathomodulation on pulse wave properties in heart failure with preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Left ventricular structure and function following renal sympathetic denervation in patients with HFpEF: an echocardiographic 9-year long-term follow-up.Frontiers in cardiovascular medicine · 2024Article
- Half-Dose versus Single-Dose Gadobutrol for Extracellular Volume Measurements in Cardiac Magnetic Resonance.Journal of cardiovascular development and disease · 2023Article
- Renal Denervation Helps Preserve the Ejection Fraction by Preserving Endocardial-Endothelial Function during Heart Failure.International journal of molecular sciences · 2023Article
- Disease- and sex-specific differences in patients with heart valve disease: a proteome study.Life science alliance · 2023Article
- Cardiac Magnetic Resonance in Hypertensive Heart Disease: Time for a New Chapter.Diagnostics (Basel, Switzerland) · 2022Review
- Subclinical HMOD in Hypertension: Left Ventricular Diastolic Dysfunction.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Review
- Myocardial Extracellular Volume Fraction Measured by Cardiac Magnetic Resonance Imaging Negatively Correlates With Cardiomyocyte Breadth in a Healthy Porcine Model.Frontiers in cardiovascular medicine · 2022Article
- Circulatory efficiency in patients with severe aortic valve stenosis before and after aortic valve replacement.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Estimation of total collagen volume: a T1 mapping versus histological comparison study in healthy Landrace pigs.The international journal of cardiovascular imaging · 2020Article
- Cardiac Myxomas Show Elevated Native T1, T2 Relaxation Time and ECV on Parametric CMR.Frontiers in cardiovascular medicine · 2020Article
- Effect of renal denervation procedure on left ventricular mass, myocardial strain and diastolic function by CMR on a 12-month follow-up.Japanese journal of radiology · 2019Article
- New Approaches in the Management of Sudden Cardiac Death in Patients with Heart Failure-Targeting the Sympathetic Nervous System.International journal of molecular sciences · 2019Review
- Sympathetic Activation in Hypertensive Chronic Kidney Disease - A Stimulus for Cardiac Arrhythmias and Sudden Cardiac Death?Frontiers in physiology · 2019Review
- Specific Afferent Renal Denervation Prevents Reduction in Neuronal Nitric Oxide Synthase Within the Paraventricular Nucleus in Rats With Chronic Heart Failure.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Renal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Long-term effects of multielectrode renal denervation on cardiac adaptations in resistant hypertensive patients with left ventricular hypertrophy.Journal of human hypertension · 2016Observational
- Renal Afferents.Current hypertension reports · 2016Review
- Renal sympathetic denervation in therapy resistant hypertension - pathophysiological aspects and predictors for treatment success.World journal of cardiology · 2016Review
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertensive cardiomyopathy is characterized by myocyte hypertrophy and interstitial fibrosis. The effects of renal denervation (RD) on the heart are poorly understood. New magnetic resonance imaging techniques (extracellular volume fraction) permit the quantitative assessment of myocardial fibrosis. Our aim was to study the effects of RD on myocardial fibrosis. METHODS AND
resultsTwenty‐three patients with resistant hypertension undergoing RD and 5 resistant hypertensive controls were prospectively included. Cardiac magnetic resonance imaging at 1.5 T was performed before RD and at 6‐month follow‐up. Indexed left ventricular mass, septal extracellular volume fraction, and indexed absolute extracellular volume (a quantitative measure of extracellular matrix) were quantified. All data are reported as mean±SD deviation (median). Decreases in systolic (161.96±19.09 [160] versus 144.78±16.48 [143] mm Hg, P<0.0001) and diastolic (85.61±12.88 [83] versus 80.39±11.93 [81] mm Hg, P=0.018) blood pressures and in indexed left ventricular mass (41.83±10.20 [41.59] versus 37.72±7.44 [38.49] g/m1.7, P=0.001) were observed at follow‐up only in RD patients. No significant differences in extracellular volume were found (26.24±3.92% [26.06%] versus 25.74±4.53% [25.63%], P=0.605). A significant decrease in absolute extracellular volume was observed after 6 months in RD patients exclusively (10.36±2.25 [10.79] versus 9.25±2.38 [9.79] mL/m1.7, P=0.031). This effect was observed independently of blood pressure reduction.
conclusionsRD significantly decreases left ventricular mass, while extracellular volume remains stable. Our results suggest that the observed left ventricular mass decrease was due not exclusively to a reversion of myocyte hypertrophy but also to an additional reduction in collagen content, indicating interstitial myocardial fibrosis.
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