ArticleScientific reports2014
Two-dimensional layered MoS₂ biosensors enable highly sensitive detection of biomolecules.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Advanced Synthesis and Unique Properties of 2D Transition Metal Dichalcogenides for Realizing Next-Generation Applications.ACS materials Au · 2025Review
- Simulation-Based Performance Assessment of Bulk Junctionless FET with Asymmetric Source/Drain for Ultrasensitive Detection of Biomolecules.Biosensors · 2025Article
- 2D Materials: From Design and Synthesis to Applications in Electrical and Electrochemical Biosensors.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Biological Sensing Using Vertical MoSBiosensors · 2025Article
- Quantum Simulation Study of Ultrascaled Label-Free DNA Sensors Based on Sub-10 nm Dielectric-Modulated TMD FETs: Sensitivity Enhancement Through Downscaling.Micromachines · 2025Article
- Unveiling the Radiative Electron-Hole Recombination of MoSJournal of fluorescence · 2025Article
- A Novel Bulk Planar Junctionless Field-Effect Transistor for High-Performance Biosensing.Biosensors · 2025Article
- High-performance HRSC advances · 2024Article
- Dynamic STEM-EELS for single-atom and defect measurement during electron beam transformations.Science advances · 2024Article
- Thermal Scanning-Probe Lithography for Broad-Band On-Demand Plasmonic Nanostructures on Transparent Substrates.ACS applied nano materials · 2023Article
- Advances in field-effect biosensors towards point-of-use.Nanotechnology · 2023Review
- Electrochemical aptasensor based on the engineered core-shell MOF nanostructures for the detection of tumor antigens.Journal of nanobiotechnology · 2023Review
- Compact Modeling of Two-Dimensional Field-Effect Biosensors.Sensors (Basel, Switzerland) · 2023Article
- High-Figure-of-Merit Biosensing and Enhanced Excitonic Absorption in an MoSMicromachines · 2023Article
- Two-Dimensional Transition Metal Dichalcogenide Based Biosensors: From Fundamentals to Healthcare Applications.Biosensors · 2023Review
- Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoSNature communications · 2022Article
- A detailed investigation of dielectric-modulated dual-gate TMD FET based label-free biosensor via analytical modelling.Scientific reports · 2022Article
- Two-dimensional nanostructures based '-onics' and '-omics' in personalized medicine.Nanophotonics (Berlin, Germany) · 2022Review
- Review
- Biomedical Applications of an Ultra-Sensitive Surface Plasmon Resonance Biosensor Based on Smart MXene Quantum Dots (SMQDs).Biosensors · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a MoS2 biosensor to electrically detect prostate specific antigen (PSA) in a highly sensitive and label-free manner. Unlike previous MoS2-FET-based biosensors, the device configuration of our biosensors does not require a dielectric layer such as HfO2 due to the hydrophobicity of MoS2. Such an oxide-free operation improves sensitivity and simplifies sensor design. For a quantitative and selective detection of PSA antigen, anti-PSA antibody was immobilized on the sensor surface. Then, introduction of PSA antigen, into the anti-PSA immobilized sensor surface resulted in a lable-free immunoassary format. Measured off-state current of the device showed a significant decrease as the applied PSA concentration was increased. The minimum detectable concentration of PSA is 1 pg/mL, which is several orders of magnitude below the clinical cut-off level of ~4 ng/mL. In addition, we also provide a systematic theoretical analysis of the sensor platform - including the charge state of protein at the specific pH level, and self-consistent channel transport. Taken together, the experimental demonstration and the theoretical framework provide a comprehensive description of the performance potential of dielectric-free MoS2-based biosensor technology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.