Evidence map›Paper›PMID 25516139›Full record

Trial reportBMJ (Clinical research ed.)2014

Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial.

Sandy Slow, Christopher M Florkowski, Stephen T Chambers, Patricia C Priest, Alistair W Stewart, Lance C Jennings, John H Livesey, Carlos A Camargo, Robert Scragg, David R Murdoch

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Sandy SlowDepartment of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand sandy.slow@otago.ac.nz.
Christopher M FlorkowskiDepartment of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand.
Stephen T ChambersDepartment of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand Department of Infectious Diseases, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand.
Patricia C PriestDepartment of Preventive and Social Medicine, University of Otago, PO Box 913, Dunedin, New Zealand.
Alistair W StewartSchool of Population Health, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Lance C JenningsDepartment of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand.
John H LiveseyCanterbury Health Laboratories, PO Box 151, Christchurch, New Zealand.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, 326 Cambridge Street, Suite 410, Boston, MA 02114, USA.
Robert ScraggSchool of Population Health, University of Auckland, Private Bag 92019, Auckland, New Zealand.
David R MurdochDepartment of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand.
University of Otago · NZCanterbury Health Laboratories · NZUniversity of Auckland · NZChristchurch Hospital · NZHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether supplementation with vitamin D improves resilience to the adverse effects of earthquakes.

designOpportunistic addition to an established randomised double blind placebo controlled trial.

settingChristchurch, New Zealand, where a prolonged series of catastrophic earthquakes beginning on 4 September 2010 occurred, which caused widespread destruction, fatalities, and extensive psychological damage.

participants322 healthy adults (241 women; 81 men) aged 18-67 who were already participating in the vitamin D and acute respiratory infections study (VIDARIS) between February 2010 and November 2011.

interventionParticipants were randomised to receive an oral dose of either 200,000 IU vitamin D3 monthly for two months then 100,000 IU monthly (n=161) or placebo (n=161) for a total of 18 months.

main outcome measureThis is a post hoc analysis from the previously published VIDARIS trial. The primary endpoint in the current analysis was the self reported effects and overall adverse impact of the Christchurch earthquakes as assessed by questionnaire four months after the most destructive earthquake on 22 February 2011, which was used as the index event. The secondary end point was the number of "psychological" adverse events that participants reported at their usual monthly appointments as part of the original VIDARIS trial.

results308 participants completed the earthquake impact questionnaire (n=152 in the vitamin D group and 156 in the placebo group). There was no significant difference in the number of self reported adverse effects between those receiving vitamin D supplementation and those receiving placebo. There was also no difference in the overall adverse impact score between treatment groups (χ(2) P=0.44). The exception was that those in the vitamin D group experienced more adverse effects on family relationships (22% v 13%; χ(2) P=0.03). The number of psychological adverse events-such as fatigue, stress, anxiety, and insomnia-that participants reported at their usual monthly appointments was significantly higher after the earthquake (χ(2) P=0.007) but did not differ between treatment groups.

conclusionIn this trial, vitamin D supplementation did not reduce the adverse impact of earthquakes in healthy adults. Trial registration Australian New Zealand Clinical Trials Registry (anzctr.org.au) ACTRN12609000486224.

Indexed as

EarthquakesAdministration, OralAdultAgedAnxietyCholecalciferolDietary SupplementsDouble-Blind MethodFatigueFemaleHumansMaleMiddle AgedNew ZealandSleep Initiation and Maintenance DisordersSurveys and QuestionnairesCholecalciferolVitamins

Identifiers

PMID25516139
PMCPMC4267197
OpenAlexW2140769511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.