ArticleBrain : a journal of neurology2015
Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering.
Article in Brain : a journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Non-Protein-Coding RNA Instability in the Human Postmortem Brain.Toxicologic pathology · 2026Article
- Abnormal local markers of sleep homeostasis in patients with focal epilepsy.Brain communications · 2026Article
- Direct intracranial EEG evidence for a local breakdown in normal sleep homeostasis at the human seizure onset zone.medRxiv : the preprint server for health sciences · 2025Article
- Aberrant activation of the mTOR signaling pathway in Rasmussen encephalitis.Scientific reports · 2025Article
- Modeling the Interictal Epileptic State for Therapeutic Development with Tetanus Toxin.Brain sciences · 2024Review
- Spike-induced cytoarchitectonic changes in epileptic human cortex are reduced via MAP2K inhibition.Brain communications · 2024Article
- INTUITION: a data platform to integrate human epilepsy clinical care and support for discovery.Frontiers in digital health · 2023Article
- Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs-An exploratory study.Frontiers in cellular neuroscience · 2023Article
- Drug-resistant epilepsy: Drug target hypothesis and beyond the receptors.Epilepsia open · 2022Review
- What value can TSPO PET bring for epilepsy treatment?European journal of nuclear medicine and molecular imaging · 2021Review
- Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.Molecular medicine reports · 2021Article
- Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients.Molecular brain · 2021Article
- Focal cortical dysplasia type 1.Brain pathology (Zurich, Switzerland) · 2021Review
- Automated fusion of multimodal imaging data for identifying epileptogenic lesions in patients with inconclusive magnetic resonance imaging.Human brain mapping · 2021Article
- Aberrant Complement System Activation in Neurological Disorders.International journal of molecular sciences · 2021Review
- Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain.Scientific reports · 2021Article
- Modulation of locomotor behaviors by location-specific epileptic spiking and seizures.Epilepsy & behavior : E&B · 2021Article
- The good, the bad, and the opportunities of the complement system in neurodegenerative disease.Journal of neuroinflammation · 2020Review
- DUSP4 appears to be a highly localized endogenous inhibitor of epileptic signaling in human neocortex.Neurobiology of disease · 2020Article
- Identifying targets for preventing epilepsy using systems biology of the human brain.Neuropharmacology · 2020Review
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Authors and funding
11 authors at 3 institutions in 1 country.
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Abstract
Although epilepsy is associated with a variety of abnormalities, exactly why some brain regions produce seizures and others do not is not known. We developed a method to identify cellular changes in human epileptic neocortex using transcriptional clustering. A paired analysis of high and low spiking tissues recorded in vivo from 15 patients predicted 11 cell-specific changes together with their 'cellular interactome'. These predictions were validated histologically revealing millimetre-sized 'microlesions' together with a global increase in vascularity and microglia. Microlesions were easily identified in deeper cortical layers using the neuronal marker NeuN, showed a marked reduction in neuronal processes, and were associated with nearby activation of MAPK/CREB signalling, a marker of epileptic activity, in superficial layers. Microlesions constitute a common, undiscovered layer-specific abnormality of neuronal connectivity in human neocortex that may be responsible for many 'non-lesional' forms of epilepsy. The transcriptional clustering approach used here could be applied more broadly to predict cellular differences in other brain and complex tissue disorders.
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