ArticleJournal of the American Geriatrics Society2014
Associations between inflammation and cognitive function in African Americans and European Americans.
Article in Journal of the American Geriatrics Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07284316 (Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance: A Randomized Clinical Trial
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Cytokines and immune biomarkers in neurodegeneration and cognitive function: A systematic review among individuals of African ancestry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Effects of Exercise Interventions and Physical Activity Behavior on Cancer Related Cognitive Impairments: A Systematic Review.BioMed research international · 2016Pooled it
- Circulating Mediators of Apoptosis and Inflammation in Aging; Physical Exercise Intervention.International journal of environmental research and public health · 2021Trial
- Increase in the Inflammatory Marker GlycA over 13 Years in Young Adults Is Associated with Poorer Cognitive Function in Midlife.PloS one · 2015Trial
- Pathways from chronic stress to cognitive decline: A multi-cohort mediation analysis of inflammation and immune-related gene expression.Brain, behavior, & immunity - health · 2026Article
- Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study.BMC medicine · 2026Article
- Exercise: Just What the Doctor Ordered, But Why? Elucidating Mechanisms for Women's Increased High-Density Lipoprotein Benefit From Exercise and for the Health ABC Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Article
- Biopsychosocial contexts influence adult cognitive function concurrently and longitudinally.Brain, behavior, & immunity - health · 2024Article
- Serum levels of IL-6 are associated with cognitive impairment in the salus in apulia population-based study.Heliyon · 2023Article
- Mediation effects of diabetes and inflammation on the relationship of obesity to cognitive impairment in African Americans.Journal of the American Geriatrics Society · 2022Review
- Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants.Molecular psychiatry · 2022Article
- Acute versus chronic inflammatory markers and cognition in older black adults: Results from the Minority Aging Research Study.Brain, behavior, and immunity · 2022Article
- Inflammatory markers and tract-based structural connectomics in older adults with a preliminary exploration of associations by race.Brain imaging and behavior · 2022Article
- The neuroinflammatory marker sTNFR2 relates to worse cognition and tau in women across the Alzheimer's disease spectrum.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Alzheimer's disease: a step closer to understanding type 3 diabetes in African Americans.Metabolic brain disease · 2021Article
- Reply to YasumaAmerican journal of respiratory and critical care medicine · 2021Article
- Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.Translational psychiatry · 2021Article
- Article
- Association between anti-inflammatory interleukin-10 and executive function in African American women at risk for Alzheimer's disease.Journal of clinical and experimental neuropsychology · 2020Article
- Decline in Handgrip Strength From Midlife to Late-Life is Associated With Dementia in a Japanese Community: The Hisayama Study.Journal of epidemiology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo examine associations between specific inflammatory biomarkers and cognitive function in African Americans (AAs) and European Americans (EAs) with prevalent vascular risk factors.
designCross-sectional analysis using generalized estimating equations to account for familial clustering; standardized β-coefficients, adjusted for age, sex, and education are reported.
settingCommunity cohort study in Jackson, Mississippi, and Rochester, Minnesota.
participantsGenetic Epidemiology Network of Arteriopathy (GENOA)-Genetics of Microangiopathic Brain Injury (GMBI) Study participants. MEASUREMENTS: Associations between inflammation (high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, soluble tumor necrosis factor (TNF) receptor 1 and 2 (sTNFR1, sTNFR2)) and cognitive function (global, processing speed, language, memory, and executive function) were examined in AAs and EAs (N = 1,965; aged 26-95, 64% women, 52% AA, 75% with hypertension).
resultsIn AAs, higher sTNFR2 was associated with poorer cognition in all domains (global: -0.11, P = .009; processing speed: -0.11, P < .001; language: -0.08, P = .002; memory: -0.09, P = .008; executive function: -0.07, P = .03); sTNFR1 was associated with slower processing speed (-0.08, P < .001) and poorer executive function (-0.08, P = .008); higher CRP was associated with slower processing speed (-0.04, P = .024), and higher IL6 was associated with poorer executive function (-0.07, P = .02). In EA, only higher sTNFR1 was associated with slower processing speed (-0.05, P = .007). Associations were not found between cognition and sTNFR2, CRP, or IL6 in EA.
conclusionIn a population with high vascular risk, adverse associations between inflammation and cognitive function were especially apparent in AAs, primarily involving markers of TNFα activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.