ReviewWorld journal of pediatrics : WJP2014
Ontogeny of the mammalian kidney: expression of aquaporins 1, 2, 3, and 4.
Review in World journal of pediatrics : WJP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Aquaporins in Fetal Development.Advances in experimental medicine and biology · 2023Article
- ACancers · 2021Article
- Article
- Aquaporin1-3 expression in normal and hydronephrotic kidneys in the human fetus.Pediatric research · 2019Article
- The Pronephros; a Fresh Perspective.Integrative and comparative biology · 2019Review
- Lipidomic and proteomic analysis of exosomes from mouse cortical collecting duct cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- How impaired efficacy happened between Gancao and Yuanhua: Compounds, targets and pathways.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDetermining the expression and functions of aquaporins (AQPs) in the adult kidney has generated important information about the roles of this protein family in the renal regulation of water homeostasis. However, limited information describes the expression of AQPs in fetal kidneys, and most reports on fetal renal AQPs originate from animal studies. Although there are the maturation and regulation of the renal-concentrating mechanism, the ways in which changes in the expression of AQPs contribute to the formation of urine during the perinatal period remain unclear. DATA SOURCES: This review summarizes current knowledge about the spatial and temporal expression patterns of AQP1, AQP2, AQP3, and AQP4 in the fetal and postnatal kidneys in different animal species and in human beings.
resultsAQP1 and AQP2 expression can be detected earlier in gestation in human beings and sheep compared with mice and rats. AQP1 expression is detected earlier in the proximal tubules than the expression of AQP2, AQP3, and AQP4 in the collecting ducts.
conclusionFurther studies investigating the regulation of AQPs during kidney development may provide insights into normal water-handling mechanisms and the pathophysiology of fetal kidneys, which may determine new directions for the clinical treatment of kidney diseases.
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Registered trials
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