Evidence map›Paper›PMID 25515697›Full record

ReviewCurrent osteoporosis reports2015

Biomechanical aspects of the muscle-bone interaction.

Keith G Avin, Susan A Bloomfield, Ted S Gross, Stuart J Warden

Abstract readReview
In one paragraph

Review in Current osteoporosis reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Transcriptional Profiling of Muscle in Females With Distal Radius Fracture and Functional Sarcopenia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Keith G AvinCenter for Translational Musculoskeletal Research and Department of Physical Therapy, School of the Health and Rehabilitation Sciences, Indiana University, 1140 W. Michigan St., CF-120, Indianapolis, IN, USA, keigavin@iu.edu.
Susan A Bloomfield
Ted S Gross
Stuart J Warden

Funding

Muscle Atrophy and Bone AnabolismR01AR064735 · NIAMS · UNIVERSITY OF WASHINGTON · PI GROSS, TED S. · 2014 to 2020
$1.8M
Neuronal Modulation of Focal Bone HomeostasisR01AR060304 · NIAMS · UNIVERSITY OF WASHINGTON · PI GROSS, TED S. · 2010 to 2014
$1.7M
Sustainability of exercise-induced gains in bone structure and estimated strengthR01AR057740 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI WARDEN, STUART J · 2010 to 2013
$1.1M
NIAMS NIH HHS AR057740NIAMS NIH HHS AR60304NIAMS NIH HHS AR64735NIAMS NIH HHS R01 AR057740NIAMS NIH HHS R01 AR060304NIAMS NIH HHS R01 AR064735
6 · The paper itself

Abstract

There is growing interest in the interaction between skeletal muscle and bone, particularly at the genetic and molecular levels. However, the genetic and molecular linkages between muscle and bone are achieved only within the context of the essential mechanical coupling of the tissues. This biomechanical and physiological linkage is readily evident as muscles attach to bone and induce exposure to varied mechanical stimuli via functional activity. The responsiveness of bone cells to mechanical stimuli, or their absence, is well established. However, questions remain regarding how muscle forces applied to bone serve to modulate bone homeostasis and adaptation. Similarly, the contributions of varied, but unique, stimuli generated by muscle to bone (such as low-magnitude, high-frequency stimuli) remains to be established. The current article focuses upon the mechanical relationship between muscle and bone. In doing so, we explore the stimuli that muscle imparts upon bone, models that enable investigation of this relationship, and recent data generated by these models.

Indexed as

Biomechanical PhenomenaBone and BonesHumansMuscle, Skeletal

Identifiers

PMID25515697
PMCPMC4306629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.