ArticlePlant molecular biology2015
Rice phenylalanine ammonia-lyase gene OsPAL4 is associated with broad spectrum disease resistance.
Article in Plant molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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101 citing papers in PubMed, 222 citations in OpenAlex.
- Comprehensive Profiling of the RicePlants (Basel, Switzerland) · 2026Article
- OsPAL2;1 and OsPAL2;3 are Key Regulators of Phenolic Acid to Modulate Allelopathy and Rhizosphere Microbiome in Rice.Rice (New York, N.Y.) · 2026Article
- Genome-wide analysis and expression profiling of the phenylalanine ammonia-lyase gene family in Chrysanthemum morifolium.BMC plant biology · 2026Article
- From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- High nitrogen-induced changes in rhizosphere microbial community structure can modulate disease susceptibility to the rice blast.Environmental microbiome · 2026Article
- OsSTK-Mediated Sakuranetin Biosynthesis and Carbon Flux Orchestrate Growth and Defence in Rice.Plant biotechnology journal · 2026Article
- The rice cellulose synthase-like D4 gene (PeerJ · 2026Article
- SgPAL1/2 confers anthracnose resistance in Stylosanthes guianensis by modulating lignin content and monomer ratios.BMC plant biology · 2025Article
- Time-Series Comparative Transcriptome Analyses of Two Potato Cultivars with Different Verticillium Wilt Resistance.Plants (Basel, Switzerland) · 2025Article
- Article
- Phenylalanine Ammonia-Lyase GhPAL9 Confers Resistance to Verticillium Wilt in Cotton.International journal of molecular sciences · 2025Article
- Salicylic acid accumulation: emerging molecular players and novel perspectives on plant development and nutrition.Journal of experimental botany · 2025Review
- IDD10-NAC079 transcription factor complex regulates sheath blight resistance by inhibiting ethylene signaling in rice.Journal of advanced research · 2025Article
- Article
- Citrate pretreatment promotes rice (Plant biotechnology (Tokyo, Japan) · 2025Article
- A WRKY transcription factor confers broad-spectrum resistance to biotic stresses and yield stability in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Metabolomic profiling ofFrontiers in plant science · 2025Article
- A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis.PLoS pathogens · 2025Article
- Divergent response associates with the differential amplitudes of immunity againstFrontiers in plant science · 2025Article
41 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most agronomically important traits, including resistance against pathogens, are governed by quantitative trait loci (QTL). QTL-mediated resistance shows promise of being effective and long-lasting against diverse pathogens. Identification of genes controlling QTL-based disease resistance contributes to breeding for cultivars that exhibit high and stable resistance. Several defense response genes have been successfully used as good predictors and contributors to QTL-based resistance against several devastating rice diseases. In this study, we identified and characterized a rice (Oryza sativa) mutant line containing a 750 bp deletion in the second exon of OsPAL4, a member of the phenylalanine ammonia-lyase gene family. OsPAL4 clusters with three additional OsPAL genes that co-localize with QTL for bacterial blight and sheath blight disease resistance on rice chromosome 2. Self-pollination of heterozygous ospal4 mutant lines produced no homozygous progeny, suggesting that homozygosity for the mutation is lethal. The heterozygous ospal4 mutant line exhibited increased susceptibility to three distinct rice diseases, bacterial blight, sheath blight, and rice blast. Mutation of OsPAL4 increased expression of the OsPAL2 gene and decreased the expression of the unlinked OsPAL6 gene. OsPAL2 function is not redundant because the changes in expression did not compensate for loss of disease resistance. OsPAL6 co-localizes with a QTL for rice blast resistance, and is down-regulated in the ospal4 mutant line; this may explain enhanced susceptibility to Magnoporthe oryzae. Overall, these results suggest that OsPAL4 and possibly OsPAL6 are key contributors to resistance governed by QTL and are potential breeding targets for improved broad-spectrum disease resistance in rice.
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