ArticleParasites & vectors2014
Seroprevalence screening for the West Nile virus in Malaysia's Orang Asli population.
Article in Parasites & vectors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human West Nile virus infection: a meta-analysis of recent global data (2019-24).Journal of global health · 2025Pooled it
- Serological evidence of West Nile virus circulation in Indonesia: Initial insights into an underrecognized flavivirus threat.PloS one · 2026Article
- Circulation of West Nile virus in mosquitoes approximate to the migratory bird stopover in West Coast Malaysia.PLoS neglected tropical diseases · 2023Article
- Serological and molecular surveillance of West Nile virus in domesticated mammals of peninsular Malaysia.Frontiers in veterinary science · 2023Article
- Exposure to Zoonotic West Nile Virus in Long-Tailed Macaques and Bats in Peninsular Malaysia.Animals : an open access journal from MDPI · 2020Article
- Evidence of West Nile virus infection in migratory and resident wild birds in west coast of peninsular Malaysia.One health (Amsterdam, Netherlands) · 2020Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWest Nile virus (WNV) infection is an emerging zoonotic disease caused by an RNA virus of the genus Flavivirus. WNV is preserved in the environment through cyclic transmission, with mosquitoes, particularly Culex species, serving as a vector, birds as an amplifying host and humans and other mammals as dead-end hosts. To date, no studies have been carried out to determine the prevalence of the WNV antibody in Malaysia. The aim of this study was to screen for the seroprevalence of the WNV in Malaysia's Orang Asli population.
methodsSerum samples of 742 Orang Asli were collected in seven states in peninsular Malaysia. The samples were assessed to determine the seroprevalence of WNV immunoglobulin (Ig)G with the WNV IgG enzyme-linked immunosorbent assay (ELISA) method. For each individual, we documented the demographic factors. Anti-dengue and anti-tick-borne encephalitis virus IgG ELISA were also performed to rule out a cross reaction. All statistical analyses were performed using the GraphPad Prism 6 (GraphPad Software, Inc.); p values of less than 0.05 were considered significant.
resultsThe serosurvey included 298 men (40.16%) and 444 women (59.84%) of Malaysia's Orang Asli. Anti-WNV IgG was found in 9 of the 742 samples (1.21%). The seroprevalence was 0.67% (2 of 298) in men and 1.58% (7 of 444) in women. The presence of anti-WNV IgG was found not to be associated with gender but, however, did correlate with age. The peak seroprevalence was found to be 2.06% (2 of 97) in individuals between 30 to 42 years of age.
conclusionsNo previous studies have examined the seroprevalence of the WNV antibody in the human population in Malaysia, and no clinical reports of infections have been made. Screening for the WNV seroprevalence is very significant because of many risk factors contribute to the presence of WNV in Malaysia, such as the abundance of Culex mosquitoes as the main vector and a high degree of biodiversity, including migratory birds that serve as a reservoir to the virus.
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