Evidence map›Paper›PMID 25515575›Full record

ArticleInvestigative ophthalmology & visual science2014

The effect of TIMP-1 on the cone mosaic in the retina of the rat model of retinitis pigmentosa.

Yerina Ji, Wan-Qing Yu, Yun Sung Eom, Farouk Bruce, Cheryl Mae Craft, Norberto M Grzywacz, Eun-Jin Lee

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  5. MMP-3 and TIMP-1 as prognostic biomarkers in VZV-induced retinal necrosis.Frontiers in cellular and infection microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yerina JiNeuroscience Graduate Program, University of Southern California, Los Angeles, California, United States Center for Vision Science and Technology, University of Southern California, Los Angeles, California, United States.
Wan-Qing YuNeuroscience Graduate Program, University of Southern California, Los Angeles, California, United States Center for Vision Science and Technology, University of Southern California, Los Angeles, California, United States.
Yun Sung EomDepartment of Biomedical Engineering, University of Southern California, Los Angeles, California, United States.
Farouk BruceDepartment of Biomedical Engineering, University of Southern California, Los Angeles, California, United States.
Cheryl Mae CraftNeuroscience Graduate Program, University of Southern California, Los Angeles, California, United States Mary D. Allen Laboratory for Vision Research, Keck School of Medicine of the University of Southern California, USC Eye Institute, Los Angeles, California, United States.
Norberto M GrzywaczNeuroscience Graduate Program, University of Southern California, Los Angeles, California, United States Department of Electrical Engineering, University of Southern California, Los Angeles, California, United States.
Eun-Jin LeeCenter for Vision Science and Technology, University of Southern California, Los Angeles, California, United States.
University of Southern California · USSouthern California Eye Institute · US

Funding

VISION RESEARCHP30EY003040 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 1985 to 2013
$7.0M
Mid-Level Vision Systems for Low VisionR01EY016093 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRZYWACZ, NORBERTO M · 2007 to 2011
$6.0M
Development of Retinal Receptive FieldsR01EY011170 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRZYWACZ, NORBERTO M · 1997 to 2006
$2.0M
NEI NIH HHS EY016093NEI NIH HHS EY03040NEI NIH HHS EY11170NEI NIH HHS P30 EY003040NEI NIH HHS R01 EY011170NEI NIH HHS R01 EY016093
6 · The paper itself

Abstract

purposeThe array of photoreceptors found in normal retinas provides uniform and regular sampling of the visual space. In contrast, cones in retinas of the S334ter-line-3 rat model for RP migrate to form a mosaic of rings, leaving large holes with few or no photoreceptors. Similar mosaics appear in human patients with other forms of retinal dystrophy. In the current study, we aimed to investigate the effect of tissue inhibitor of metalloproteinase-1 (TIMP-1) on the mosaic of cones in S334ter-line-3 rat retinas. We focused on TIMP-1 because it is one of the regulators of the extracellular matrix important for cellular migration.

methodsImmunohistochemistry was performed to reveal M-opsin cone cells (M-cone) and the results were quantified to test statistically whether or not TIMP-1 restores the mosaics to normal. In particular, the tests focused on the Voronoi and nearest-neighbor distance analyses.

resultsOur tests indicated that TIMP-1 led to significant disruption of the M-opsin cone rings in S334ter-line-3 rat retinas and resulted in almost complete homogeneous mosaics. In addition, TIMP-1 induced the M-cone spatial distribution to become closer to random with decreased regularity in S334ter-line-3 rat retinas.

conclusionsThese findings confirm that TIMP-1 induced M-cone mosaics in S334ter-line-3 to gain homogeneity without reaching the degree of regularity seen in normal retinal mosaics. Even if TIMP-1 fails to promote regularity, the effects of this drug on homogeneity appear to be so dramatic that TIMP-1 may be a potential therapeutic agent. TIMP-1 improves sampling of the visual field simply by causing homogeneity.

Indexed as

AnimalsApoptosisDisease Models, AnimalImmunohistochemistryIn Situ Nick-End LabelingIntravitreal InjectionsMatrix Metalloproteinase InhibitorsMicroscopy, ConfocalRatsRats, Sprague-DawleyRetinal Cone Photoreceptor CellsRetinitis PigmentosaTissue Inhibitor of Metalloproteinase-1Treatment OutcomeMatrix Metalloproteinase InhibitorsTissue Inhibitor of Metalloproteinase-1conesmosaicretinitis pigmentosaTIMP-1

Identifiers

PMID25515575
PMCPMC4294290
OpenAlexW2319412464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.