ArticleJournal of exposure science & environmental epidemiology2015
Prenatal exposure to pyrethroid insecticides and birth outcomes in Rural Northern China.
Article in Journal of exposure science & environmental epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Pesticide exposure and child growth in low- and middle-income countries: A systematic review.Environmental research · 2022Pooled it
- Environmental Exposure to Non-Persistent Endocrine Disrupting Chemicals and Endometriosis: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Mercury-induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium-glutathione axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Association between prenatal exposure to residential pyrethroid insecticides and congenital hypothyroidism using propensity score matching.Scientific reports · 2026Article
- Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- The association between prenatal pyrethroids exposure and children's health - current research.International journal of occupational medicine and environmental health · 2024Review
- Pesticide exposure, birth size, and gestational age in the ISA birth cohort, Costa Rica.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Exposure Patterns of Multiple Pesticides and Urinary Alterations of Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) among Pregnant Women.Environment & health (Washington, D.C.) · 2024Article
- Pyrethroid pesticide exposure and placental effects.Molecular and cellular endocrinology · 2023Review
- Literature landscape of neurodevelopment and pesticides: A scoping review of methodologies.Global epidemiology · 2023Article
- Article
- A systematic review of human biomonitoring studies of 3-phenoxybenzoic acid, a urinary biomarker pyrethroid insecticide exposure, 1997 to 2019.Hygiene and environmental health advances · 2022Article
- Article
- Characterization of Urinary Pesticide Metabolite Concentrations of Pregnant Women in Suriname.Toxics · 2022Article
- First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth.International journal of environmental research and public health · 2022Article
- Maternal and fetal tissue distribution of α-cypermethrin and permethrin in pregnant CD-1 mice.Environmental advances · 2022Article
- A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides.Critical reviews in toxicology · 2022Review
- Prenatal exposure to insecticides and child cardiometabolic risk factors in the VHEMBE birth cohort.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Association between maternal insecticide use and otitis media in one-year-old children in the Japan Environment and Children's Study.Scientific reports · 2022Article
- Prenatal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-dichlorophenoxyacetic acid and size at birth in urban pregnant women.Environmental research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although pyrethroid insecticides are widely used, little is known about potential adverse effects on fetal growth. Participating 454 mother-infant pairs were recruited from a prospective birth cohort in rural northern China between September 2010 and 2012. We measured five non-specific pyrethroid metabolites in maternal urine at delivery and examined their association with birth outcomes including birth weight, length, head circumference, and gestational duration. The creatinine-adjusted medians of pyrethroid metabolites in urine were 0.51 μg/g for cis-DCCA, 0.65 μg/g for trans-DCCA, and 0.68 μg/g for 3-PBA. The pregnant women had substantially higher levels of urinary pyrethroid metabolites compared with those reported in developed countries. A increase in total (the sum of cis-DCCA, trans-DCCA, and 3-PBA) but not individual urinary metabolite levels was associated with a decrease in birth weight (adjusted β=-96.76 g per log10 unit increase, 95% confidence interval=-173.15 to -20.37). No associations were found between individual or total metabolite levels and birth length, head circumference, or gestational duration. We report an adverse association of prenatal exposure to pyrethroids as measured by urinary metabolites with birth weight. More studies are warranted in China given the relatively high levels of urinary metabolites in our study population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.