ArticleScientific reports2014
Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Transgenerational consequences of grandparents' smoking on grandchildren's development: a systematic review.BMJ open · 2025Pooled it
- Role of microRNAs in the pathophysiology of addiction.Wiley interdisciplinary reviews. RNA · 2021Pooled it
- Nicotine Exposure During Gestation: From Placental Dysfunction to Long-Term Neurobehavioral Outcomes.Birth defects research · 2026Review
- Multigenerational association between smoking and autism spectrum disorder: findings from a nationwide prospective cohort study.American journal of epidemiology · 2024Article
- The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and nicotine withdrawal in male rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.Cardiovascular research · 2023Article
- Preterm Birth, Developmental Smoke/Nicotine Exposure, and Life-Long Pulmonary Sequelae.Children (Basel, Switzerland) · 2023Review
- Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Establishing a three-generation prospective study: Bogalusa daughters.Journal of developmental origins of health and disease · 2020Article
- Epigenetic profiling to environmental stressors in model and non-model organisms: Ecotoxicology perspective.Environmental health and toxicology · 2018Article
- Caenorhabditis elegans as an emerging model system in environmental epigenetics.Environmental and molecular mutagenesis · 2018Review
- miR-296-3p Negatively Regulated by Nicotine Stimulates Cytoplasmic Translocation of c-Myc via MK2 to Suppress Chemotherapy Resistance.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis.American journal of respiratory cell and molecular biology · 2017Article
- MicroRNA expression profiles during cotton (Gossypium hirsutum L) fiber early development.Scientific reports · 2017Article
- Analysis of plasma microRNA expression profiles revealed different cancer susceptibility in healthy young adult smokers and middle-aged smokers.Oncotarget · 2016Article
- Identification and characterization of microRNAs in the plant parasitic root-knot nematode Meloidogyne incognita using deep sequencing.Functional & integrative genomics · 2016Article
- Effects of addictive drugs on adult neural stem/progenitor cells.Cellular and molecular life sciences : CMLS · 2016Review
- Consumption of Substances of Abuse during Pregnancy Increases Consumption in Offspring: Possible Underlying Mechanisms.Frontiers in nutrition · 2016Review
- Characterizing Social Interaction in Tobacco-Oriented Social Networks: An Empirical Analysis.Scientific reports · 2015Article
- Variable directionality of gene expression changes across generations does not constitute negative evidence of epigenetic inheritance.Environmental epigenetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Early developmental stages are highly sensitive to stress and it has been reported that pre-conditioning with tobacco smoking during adolescence predisposes those youngsters to become smokers as adults. However, the molecular mechanisms of nicotine-induced transgenerational consequences are unknown. In this study, we genome-widely investigated the impact of nicotine exposure on small regulatory microRNAs (miRNAs) and its implication on health disorders at a transgenerational aspect. Our results demonstrate that nicotine exposure, even at the low dose, affected the global expression profiles of miRNAs not only in the treated worms (F0 parent generation) but also in two subsequent generations (F1 and F2, children and grandchildren). Some miRNAs were commonly affected by nicotine across two or more generations while others were specific to one. The general miRNA patterns followed a "two-hit" model as a function of nicotine exposure and abstinence. Target prediction and pathway enrichment analyses showed daf-4, daf-1, fos-1, cmk-1, and unc-30 to be potential effectors of nicotine addiction. These genes are involved in physiological states and phenotypes that paralleled previously published nicotine induced behavior. Our study offered new insights and further awareness on the transgenerational effects of nicotine exposed during the vulnerable post-embryonic stages, and identified new biomarkers for nicotine addiction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.