ArticleJournal of neurovirology2015
Genetic predictor of working memory and prefrontal function in women with HIV.
Article in Journal of neurovirology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Adaptive working memory training improved brain function in human immunodeficiency virus-seropositive patients.Annals of neurology · 2017Trial
- A rest-task fMRI study of spatial working memory in HIV-infected individuals across cognitive states.BMC medical imaging · 2026Article
- Pathogenesis of HIV-associated depression: contributing factors and underlying mechanisms.Frontiers in psychiatry · 2025Review
- Childhood trauma and genetic variation in theIBRO neuroscience reports · 2022Article
- Greater Sensorimotor Deficits and Abnormally Lower Globus Pallidus Fractional Anisotropy in HIV+ Women than in HIV+ Men.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection.Current topics in behavioral neurosciences · 2021Article
- Transcriptomic and Genetic Profiling of HIV-Associated Neurocognitive Disorders.Frontiers in molecular biosciences · 2021Review
- Neurocognitive Complications of HIV Infection in Women: Insights from the WIHS Cohort.Current topics in behavioral neurosciences · 2021Review
- Lower CSF homovanillic acid relates to higher burden of neuroinflammation and depression in people with HIV disease.Brain, behavior, and immunity · 2020Article
- COMT val158met genotype alters the effects of methamphetamine dependence on dopamine and dopamine-related executive function: preliminary findings.Psychiatry research · 2020Article
- Genetic variation in alcohol dehydrogenase is associated with neurocognition in men with HIV and history of alcohol use disorder: preliminary findings.Journal of neurovirology · 2020Article
- Comorbid HIV infection and alcohol use disorders: Converging glutamatergic and dopaminergic mechanisms underlying neurocognitive dysfunction.Brain research · 2019Review
- COMT Val158Met Polymorphism, Cardiometabolic Risk, and Nadir CD4 Synergistically Increase Risk of Neurocognitive Impairment in Men Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging.Progress in molecular biology and translational science · 2019Review
- The role of catecholamines in HIV neuropathogenesis.Brain research · 2019Review
- Verbal and spatial working memory among drug-using HIV-infected men and women.Journal of neurovirology · 2018Article
- Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy.AIDS (London, England) · 2018Article
- Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain.Scientific reports · 2017Article
- Impairments of Motor Function While Multitasking in HIV.Frontiers in human neuroscience · 2017Article
- Elevated stress is associated with prefrontal cortex dysfunction during a verbal memory task in women with HIV.Journal of neurovirology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
The Val158Met (rs4680) single-nucleotide polymorphism (SNP) of the catechol-O-methyltransferase gene (COMT) influences executive function and prefrontal function through its effect on dopamine (DA) metabolism. Both HIV and the Val allele of the Val158Met SNP are associated with compromised executive function and inefficient prefrontal function. The present study used behavioral and neuroimaging techniques to determine independent and interactive associations between HIV serostatus and COMT genotype on working memory and prefrontal function in women. For the behavioral study, 54 HIV-infected and 33 HIV-uninfected women completed the 0-, 1-, and 2-back conditions of the verbal N-back, a working memory test. For the imaging study, 36 women (23 HIV-infected, 13 HIV-uninfected) underwent functional magnetic resonance imaging (fMRI) assessments while completing the N-back task. HIV-infected women demonstrated significantly worse N-back performance compared with HIV-uninfected women (p < 0.05). A significant serostatus by genotype interaction (p < 0.01) revealed that, among Val/Val, but not Met allele carriers, HIV-infected women performed significantly worse than HIV-uninfected controls across N-back conditions (p < 0.01). Analogous to behavioral findings, a serostatus by genotype interaction revealed that HIV-infected Val/Val carriers showed significantly greater prefrontal activation compared with HIV-uninfected Val/Val carriers (p < 0.01). Conversely, HIV-uninfected Met allele carriers demonstrated significantly greater prefrontal activation compared with HIV-infected Met allele carriers. Findings suggest that the combination of HIV infection and the Val/Val COMT genotype leads to working memory deficits and altered prefrontal function in HIV-infected individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.