Evidence map›Paper›PMID 25515230›Full record

ArticleJournal of the National Cancer Institute2015

Translational cancer research: balancing prevention and treatment to combat cancer globally.

Christopher P Wild, John R Bucher, Bas W D de Jong, Joakim Dillner, Christina von Gertten, John D Groopman, Zdenko Herceg, Elaine Holmes, Reetta Holmila, Jørgen H Olsen and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  17. Article
  18. Cancer prevention: state of the art and future prospects.Journal of preventive medicine and hygiene · 2015
    Review
  19. Revisiting Alma Ata: A Blueprint for Cancer Care.Cancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Christopher P WildDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM). director@iarc.fr.
John R BucherDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Bas W D de JongDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Joakim DillnerDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Christina von GerttenDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
John D GroopmanDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Zdenko HercegDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Elaine HolmesDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Reetta HolmilaDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Jørgen H OlsenDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Ulrik RingborgDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Augustin ScalbertDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Tatsuhiro ShibataDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Martyn T SmithDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Cornelia UlrichDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
Paolo VineisDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).
John McLaughlinDirector's Office, Sections of Mechanisms of Carcinogenesis and Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (CPW, ZH, RH, AS); National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA (JRB); Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands (BWDdJ); Department of Medical Epidemiology & Biostatistics, BioBanking & Molecular Resource Infrastructure, Karolinska Institute, Stockholm, Sweden (JD); Radiation Medicine Center, Karolinska Institute, Stockholm, Sweden (CvG); Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (JDG); Department of Surgery and Cancer, Imperial College London, London, UK (EH); Danish Cancer Society Research Centre, Copenhagen, Denmark (JHO); Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden (UR); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (TS); School of Public Health, University of California, Berkeley, CA, USA (MTS); Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany (CU); Department of Epidemiology & Biostatistics, Imperial College London, London, UK (PV); Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (JM).

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MORELLO-FROSCH, RACHEL ADELE · 1987 to 2025
$74.6M
NIEHS NIH HHS P42 ES004705World Health Organization 001
6 · The paper itself

Abstract

Cancer research is drawing on the human genome project to develop new molecular-targeted treatments. This is an exciting but insufficient response to the growing, global burden of cancer, particularly as the projected increase in new cases in the coming decades is increasingly falling on developing countries. The world is not able to treat its way out of the cancer problem. However, the mechanistic insights from basic science can be harnessed to better understand cancer causes and prevention, thus underpinning a complementary public health approach to cancer control. This manuscript focuses on how new knowledge about the molecular and cellular basis of cancer, and the associated high-throughput laboratory technologies for studying those pathways, can be applied to population-based epidemiological studies, particularly in the context of large prospective cohorts with associated biobanks to provide an evidence base for cancer prevention. This integrated approach should allow a more rapid and informed translation of the research into educational and policy interventions aimed at risk reduction across a population.

Indexed as

Global HealthInterdisciplinary CommunicationTranslational Research, BiomedicalDeveloped CountriesDeveloping CountriesEarly Detection of CancerEvidence-Based MedicineHumansNeoplasmsResearch Support as Topic

Identifiers

PMID25515230
PMCPMC4334834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.