ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Evaluation of cerebrovascular impedance and wave reflection in mouse by ultrasound.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Non-invasive real-time pulsed Doppler assessment of blood flow in mouse ophthalmic artery.Cell reports methods · 2025Article
- Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model.Frontiers in aging neuroscience · 2024Article
- Interpretation of Wave Reflections in the Umbilical Arterial Segment of the Feto-Placental Circulation: Computational Modeling of the Feto-Placental Arterial Tree.IEEE transactions on bio-medical engineering · 2021Article
- Sex differences in modulation of fetoplacental vascular resistance in growth-restricted mouse fetuses following betamethasone administration: comparisons with human fetuses.American journal of obstetrics & gynecology MFM · 2021Article
- Effect of maternal betamethasone administration on feto-placental vascular resistance in the mouse†.Biology of reproduction · 2019Article
- Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Ultrasound detection of altered placental vascular morphology based on hemodynamic pulse wave reflection.American journal of physiology. Heart and circulatory physiology · 2017Article
- Magnetic resonance advection imaging of cerebrovascular pulse dynamics.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic and surgical mouse models are commonly used to study cerebrovascular disease, but their size makes invasive hemodynamic testing technically challenging. The purpose of this study was to demonstrate a noninvasive measurement of cerebrovascular impedance and wave reflection in mice using high-frequency ultrasound in the left common carotid artery (LCCA), and to examine whether microvascular changes associated with hypercapnia could be detected with such an approach. Ten mice (C57BL/6J) were studied using a high-frequency ultrasound system (40 MHz). Lumen area and blood flow waveforms were obtained from the LCCA and used to calculate pulse-wave velocity, input impedance, and reflection amplitude and transit time under both normocapnic and hypercapnic (5% CO2) ventilation. With hypercapnia, vascular resistance was observed to decrease by 87%±12%. Although the modulus of input impedance was unchanged with hypercapnia, a phase decrease indicative of increased total arterial compliance was observed at low harmonics together with an increased reflection coefficient in both the time (0.57±0.08 versus 0.68±0.08, P=0.04) and frequency domains (0.62±0.08 versus 0.73±0.06, P=0.02). Interestingly, the majority of LCCA blood flow was found to pass into the internal carotid artery (range=76% to 90%, N=3), suggesting that hemodynamic measurements in this vessel are a good metric for intracerebral reactivity in mouse.
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