ArticleSleep2015
Coronary heart disease incidence in sleep disordered breathing: the Wisconsin Sleep Cohort Study.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 96 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Obstructive Sleep Apnea on Outcomes in Acute Coronary Syndrome
Schrittmacher-basiertes Schlafapnoe Langzeit-Monitoring
Screening Moderate to Severe Obstructive Sleep Apnea With Wearable Device
Who cites it
96 citing papers in PubMed, 5 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Association Between Obstructive Sleep Apnea and Cardiovascular Risk: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Global research progress on obstructive sleep apnea in the field of radiological imaging: bibliometric and visualization analysis.Frontiers in neurology · 2025Pooled it
- A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults.NPJ primary care respiratory medicine · 2022Pooled it
- Validation of the STOP-Bang questionnaire for screening of obstructive sleep apnea in the general population and commercial drivers: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- Sleep Disturbances in Patients With Coronary Heart Disease: A Systematic Review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Pooled it
- Continuous positive airway pressure and mandibular advancement splints: the CHOICE multicentre, open-label randomised clinical trial.The European respiratory journal · 2025Trial
- Impact of short-acting vs. standard anaesthetic agents on obstructive sleep apnoea: a randomised, controlled, triple-blind trial.Anaesthesia · 2021Trial
- Nocturnal Hypoxemia and Incident Coronary Artery Disease in Obstructive Sleep Apnea: Results from the Sleep Apnea Patients in Skaraborg Study.Balkan medical journal · 2026Article
- Cardiovascular risk stratification in obstructive sleep apnea: a potential role for cardiac troponins.Sleep · 2026Article
- STOP-BANG-Defined high OSA risk is associated with left ventricular diastolic dysfunction in obese adults.Sleep & breathing = Schlaf & Atmung · 2026Article
- Downstream Impact of a Sleep Surgery Program; Optimizing Patient Care and Generating Clinical Volume.The Laryngoscope · 2026Article
- Impact of Philips device recall on adults with obstructive sleep apnea treated with PAP therapy: Results of a cross-national patient survey.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Obstructive Sleep Apnea and Coronary Artery Disease: An Overlooked Cardiovascular Risk Factor.Biomedicines · 2026Review
- Exploring the impact of a medical device recall on individuals with obstructive sleep apnea and healthcare providers: a qualitative study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Comparative analysis of cardiac autonomic dysfunction between apnea-predominant and hypopnea-predominant obstructive sleep apnea: a study matched for age, sex, and apnea-hypopnea index : Short running title: cardiovascular risk of apnea vs. hypopnea in OSA.Sleep & breathing = Schlaf & Atmung · 2025Article
- Association of nocturnal hypoxemia and white blood cell count in a multicenter cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
- The Association of Sleep Trouble and Physical Inactivity with Breast Cancer Risk in Nova Scotia: Evidence from the Atlantic PATH Cohort.International journal of environmental research and public health · 2025Article
- The effect of continuous positive airway pressure therapy on early atherosclerosis in patients with severe obstructive sleep apnea-hypopnea syndrome.Sleep & breathing = Schlaf & Atmung · 2025Article
- Validation of the efficacy of the GPSS questionnaire for screening obstructive sleep apnea.Frontiers in medicine · 2025Article
- Sleep Apnea Events Recognition Based on Polysomnographic Recordings: A Large-Scale Multi-Channel Machine Learning approach.IEEE open journal of engineering in medicine and biology · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesThe aim of the study was to determine the association of objectively measured sleep disordered breathing (SDB) with incident coronary heart disease (CHD) or heart failure (HF) in a nonclinical population.
designLongitudinal analysis of a community-dwelling cohort followed up to 24 y.
settingSleep laboratory at the Clinical Research Unit of the University of Wisconsin Hospital and Clinics.
participantsThere were 1,131 adults who completed one or more overnight polysomnography studies, were free of CHD or HF at baseline, were not treated by continuous positive airway pressure (CPAP), and followed over 24 y.
interventionsNone. MEASUREMENTS AND
resultsIn-laboratory overnight polysomnography was used to assess SDB, defined by the apnea-hypopnea index (AHI) using apnea and hypopnea events per hour of sleep. Incident CHD or HF was defined by new reports of myocardial infarction, coronary revascularization procedures, congestive heart failure, and cardiovascular deaths. We used baseline AHI as the predictor variable in survival analysis models predicting CHD or HF incidence adjusted for traditional confounders. The incidence of CHD or HF was 10.9/1,000 person-years. The mean time to event was 11.2 ± 5.8 y. After adjusting for age, sex, body mass index, and smoking, estimated hazard ratios (95% confidence interval) of incident CHD or HF were 1.5 (0.9-2.6) for AHI > 0-5, 1.9 (1.05-3.5) for AHI 5 ≤ 15, 1.8 (0.85-4.0) for AHI 15 ≤ 30, and 2.6 (1.1-6.1) for AHI > 30 compared to AHI = 0 (P trend = 0.02).
conclusionsParticipants with untreated severe sleep disordered breathing (AHI > 30) were 2.6 times more likely to have an incident coronary heart disease or heart failure compared to those without sleep disordered breathing. Our findings support the postulated adverse effects of sleep disordered breathing on coronary heart disease and heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.