ArticleSleep2015
A new model to study sleep deprivation-induced seizure.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Clinical Applications of Mobile Health Wearable-Based Sleep Monitoring: Systematic Review.JMIR mHealth and uHealth · 2020Pooled it
- Individuals with reported and novel KDM5C variants present with seizures, a feature recapitulated in a Drosophila model.Human molecular genetics · 2026Article
- Sleep drive, not total sleep amount, increases seizure risk.Nature communications · 2025Article
- Seizure Susceptibility inmicroPublication biology · 2025Article
- Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset.PLoS genetics · 2021Article
- Investigating rare and ultrarare epilepsy syndromes withFaculty reviews · 2021Review
- Regulation of the Blood-Brain Barrier by Circadian Rhythms and Sleep.Trends in neurosciences · 2019Review
- A Systematic Review on Non-mammalian Models in Epilepsy Research.Frontiers in pharmacology · 2018Article
- Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila.Scientific reports · 2017Article
- High risk of developing subsequent epilepsy in patients with sleep-disordered breathing.PloS one · 2017Article
- Drosophila sodium channel mutations: Contributions to seizure-susceptibility.Experimental neurology · 2015Review
- Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy.PloS one · 2015Article
- Attenuation of Seizures, Cognitive Deficits, and Brain Histopathology by Phytochemicals ofJournal of evidence-based integrative medicineArticle
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND STUDY
objectivesA relationship between sleep and seizures is well-described in both humans and rodent animal models; however, the mechanism underlying this relationship is unknown. Using Drosophila melanogaster mutants with seizure phenotypes, we demonstrate that seizure activity can be modified by sleep deprivation.
designSeizure activity was evaluated in an adult bang-sensitive seizure mutant, stress sensitive B (sesB(9ed4)), and in an adult temperature sensitive seizure mutant seizure (sei(ts1)) under baseline and following 12 h of sleep deprivation. The long-term effect of sleep deprivation on young, immature sesB(9ed4) flies was also assessed.
settingLaboratory.
participantsDrosophila melanogaster.
interventionsSleep deprivation. MEASUREMENTS AND
resultsSleep deprivation increased seizure susceptibility in adult sesB(9ed4)/+ and sei(ts1) mutant flies. Sleep deprivation also increased seizure susceptibility when sesB was disrupted using RNAi. The effect of sleep deprivation on seizure activity was reduced when sesB(9ed4)/+ flies were given the anti-seizure drug, valproic acid. In contrast to adult flies, sleep deprivation during early fly development resulted in chronic seizure susceptibility when sesB(9ed4)/+ became adults.
conclusionsThese findings show that Drosophila is a model organism for investigating the relationship between sleep and seizure activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.