Evidence map›Paper›PMID 25515075›Full record

ArticleEcoHealth2015

Detection of Mycobacterium tuberculosis Complex in New World Monkeys in Peru.

Marieke Rosenbaum, Patricia Mendoza, Bruno M Ghersi, Alicia K Wilbur, Amaya Perez-Brumer, Nancy Cavero Yong, Matthew R Kasper, Silvia Montano, Joseph R Zunt, Lisa Jones-Engel

Open access · bronzeAbstract read
In one paragraph

Article in EcoHealth, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pathogens (Basel, Switzerland) · 2022
    Article
  4. Zoonotic pathogens survey in free-living long-tailed macaques in Thailand.International journal of veterinary science and medicine · 2022
    Article
  5. Article
  6. Challenges to IUCN Guideline Implementation in the Rehabilitation and Release of Trafficked Primates in Peru.Primate conservation : the newsletter and journal of the IUCN/SSC Primate Specialist Group · 2021
    Article
  7. Mycobacterium tuberculosis var. tuberculosis infection in two captive black capuchins (Sapajus nigritus) in Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020
    Article
  8. Article
  9. Dynamics of Immune Responses during ExperimentalMediators of inflammation · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Marieke RosenbaumInfectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Road, North Grafton, MA, 01536, USA. marieke.rosenbaum@tufts.edu.
Patricia MendozaWildlife Health and Policy, Wildlife Conservation Society, Avenida 15 de Enero 591, Miraflores, Lima, Peru. pmendoza@wcs.org.
Bruno M GhersiDepartment of Ecology and Environmental Biology, Tulane University, 6823 St. Charles Ave., New Orleans, LA, 70118, USA. b.m.ghersi@gmail.com.
Alicia K WilburWashington National Primate Research Center, University of Washington, 1705 Pacific St NE, HSB I-039, Box 357330, Seattle, WA, 98105, USA. leeshiekw@gmail.com.
Amaya Perez-BrumerDepartment of Sociomedical Sciences, Mailman School of Public Health, Colombia University, 722 W 168th St #14, New York, NY, 10032, USA. aperezbrumer@gmail.com.
Nancy Cavero YongWildlife Health and Policy, Wildlife Conservation Society, Avenida 15 de Enero 591, Miraflores, Lima, Peru. ncavero@wcs.org.
Matthew R KasperDepartment of Bacteriology, U.S. Naval Medical Research Unit No. 6, Lima, Peru. matthew.kasper@med.navy.mil.
Silvia MontanoDepartment of Bacteriology, U.S. Naval Medical Research Unit No. 6, Lima, Peru. silvia.montano@med.navy.mil.
Joseph R ZuntDepartments of Global Health, Neurology, Epidemiology and Medicine (Infectious Disease), University of Washington, Harborview Medical Center, 325 9th Ave., Room 3EH70, Seattle, WA, 98104, USA. jzunt@u.washington.edu.
Lisa Jones-EngelWashington National Primate Research Center, University of Washington, 1705 Pacific St NE, HSB I-039, Box 357330, Seattle, WA, 98105, USA. ljengel@uw.edu.
Naval Medical Research Unit Six · PEUniversity of Washington · USHarborview Medical Center · USTufts University · USTulane University · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
YILMA SIV VACCINIA VACCINE TRIALP51RR000166 · NCRR · UNIVERSITY OF WASHINGTON · PI HU, SHIU-LOK · 1985 to 2011
$161.1M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Evolution and Emergence of Simian Retroviruses in South AsiaR01AI078229 · NIAID · UNIVERSITY OF WASHINGTON · PI BARRY, PETER A, ESCALANTE, ANANIAS ALBERTO · 2008 to 2012
$3.7M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
GSH Training GrantT32HD049339 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jennifer S Hirsch · 2006 to 2026
$3.4M
FIC NIH HHS R24 TW007988NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1TR000423NCRR NIH HHS P51 RR000166NIAID NIH HHS R01 AI078229NICHD NIH HHS T32 HD049339NIH HHS P51 OD010425NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

The Mycobacterium tuberculosis complex causes tuberculosis in humans and nonhuman primates and is a global public health concern. Standard diagnostics rely upon host immune responses to detect infection in nonhuman primates and lack sensitivity and specificity across the spectrum of mycobacterial infection in these species. We have previously shown that the Oral Swab PCR (OSP) assay, a direct pathogen detection method, can identify the presence of M. tuberculosis complex in laboratory and free-ranging Old World monkeys. Addressing the current limitations in tuberculosis diagnostics in primates, including sample acquisition and pathogen detection, this paper furthers our understanding of the presence of the tuberculosis-causing bacteria among New World monkeys in close contact with humans. Here we use the minimally invasive OSP assay, which includes buccal swab collection followed by amplification of the IS6110 repetitive nucleic acid sequence specific to M. tuberculosis complex subspecies, to detect the bacteria in the mouths of Peruvian New World monkeys. A total of 220 buccal swabs from 16 species were obtained and positive amplification of the IS6110 sequence was observed in 30 (13.6%) of the samples. To our knowledge, this is the first documentation of M. tuberculosis complex DNA in a diverse sample of Peruvian Neotropical primates.

Indexed as

Age FactorsAnimalsBacteriological TechniquesDNA, BacterialDNA, MitochondrialFemaleMaleMonkey DiseasesMycobacteriumPeruPlatyrrhiniPolymerase Chain ReactionTuberculosisDNA, BacterialDNA, Mitochondrialdirect pathogen detectionMycobacterium tuberculosis complexnew world monkeynonhuman primateoral swab PCRPerutuberculosis

Identifiers

PMID25515075
PMCPMC4470872
OpenAlexW2055137071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.