Evidence map›Paper›PMID 25515040›Full record

ArticleMolecular oncology2015

Short telomere length in peripheral blood leukocyte predicts poor prognosis and indicates an immunosuppressive phenotype in gastric cancer patients.

Falin Qu, Renli Li, Xianli He, Qiucheng Li, Shuang Xie, Li Gong, Gang Ji, Jianguo Lu, Guoqiang Bao

Abstract read
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In one paragraph

Article in Molecular oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  6. Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023
    Review
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  15. Telomere Length and Lung Cancer Mortality among Heavy Smokers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Falin QuDepartment of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Renli LiDepartment of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Xianli HeDepartment of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Qiucheng LiDepartment of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Shuang XieDepartment of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Li GongDepartment of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Gang JiXijing Hospital of Digestive Disease, The Fourth Military Medical University, Xi'an 710032, China.
Jianguo LuDepartment of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China. Electronic address: tdsurg@fmmu.edu.cn.
Guoqiang BaoDepartment of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China. Electronic address: guoqiang@fmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compelling evidences indicate that relative telomere length (RTL) in peripheral blood leukocytes (PBLs) can predict the clinical outcome of several cancers. However, to date, the prognostic value of leukocyte RTL in gastric cancer (GC) patients has not been explored. In this study, relative telomere length (RTL) in peripheral blood leukocytes (PBLs) was measured using a real-time PCR-based method in a total of 693 GC patients receiving surgical resection. The prognostic value of leukocyte RTL was first explored in the training set (112 patients) using Kaplan-Meier and Cox proportional hazards regression analyses. Then an independent cohort of 581 patients was used as a validation set. To explore potential mechanism, we detected the immunophenotypes of peripheral blood mononuclear cells and plasma concentrations of several cytokines in GC patients. Patients with short RTL showed significantly worse overall survival (OS) and relapse-free survival (RFS) than those with long RTL in all patient sets. Furthermore, leukocyte RTL and TNM stage exhibited a notable joint effect in prognosis prediction. Integration of TNM stage and leukocyte RTL significantly improved the prognosis prediction efficacy for GC. In addition, we found that patients with short RTL had a higher CD4(+) T cell percentage in PBMCs, CD19(+)IL-10(+) Breg percentage in B cells and plasma IL-10 concentration, indicating an enhanced immunosuppressive status with short leukocyte RTL. In conclusion, our study for the first time demonstrates that leukocyte RTL is an independent prognostic marker complementing TNM stage and associated with an immunosuppressive phenotype in the peripheral blood lymphocytes in GC patients.

Indexed as

Immunosuppression TherapyTelomere ShorteningCytokinesDisease-Free SurvivalFemaleHumansImmunophenotypingKaplan-Meier EstimateLeukocytes, MononuclearMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalNeoplasm StagingPhenotypePrognosisCytokinesGastric cancerLeukocyte telomere lengthPrognosisRegulatory B lymphocyte

Identifiers

PMID25515040
PMCPMC5528698

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.