ReviewEuropean journal of clinical nutrition2015
Vitamin D and thyroid disease: to D or not to D?
Review in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Association between serum vitamin D level and Graves' disease: a systematic review and meta-analysis.Nutrition journal · 2024Pooled it
- Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies.BMC endocrine disorders · 2021Pooled it
- Association between vitamin D deficiency and risk of thyroid cancer: a case-control study and a meta-analysis.Journal of endocrinological investigation · 2018Pooled it
- Pooled it
- Vitamin D Supplementation Modulates T Cell-Mediated Immunity in Humans: Results from a Randomized Control Trial.The Journal of clinical endocrinology and metabolism · 2016Trial
- The association between vitamin D and hypothyroidism: a systematic review and meta-analysis.Nutrition & metabolism · 2026Review
- Vitamin D as a central modulator of thyroid diseases: mechanisms and clinical implications.Frontiers in immunology · 2026Review
- Maternal Vitamin D Status and Its Association with Neonatal Health: Clinical Implications and Influencing Factors.Nutrients · 2025Article
- Serum Vitamin D Levels in Autoimmune and Non-Autoimmune Hypothyroidism: A Retrospective Study from Jordan.Avicenna journal of medicine · 2025Article
- Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies.Nutrition journal · 2025Article
- Unveiling the Link Between Vitamin D, Hashimoto's Thyroiditis, and Thyroid Functions: A Retrospective Study.Nutrients · 2025Article
- Vitamin D deficiency as a potential risk factor for thyroid cancer: a clinical perspective.Frontiers in nutrition · 2025Article
- Vitamin D and thyroid function of pregnant women in a sunny region: is there any connection?Revista da Associacao Medica Brasileira (1992) · 2025Article
- Cardioprotective effect of Vitamin D on cardiac hypertrophy through improvement of mitophagy and apoptosis in an experimental rat model of levothyroxine -induced hyperthyroidism.Molecular biology reports · 2024Article
- Vitamin D Deficiency Is Associated with Impaired Sensitivity to Thyroid Hormones in Euthyroid Adults.Nutrients · 2023Article
- Relationships between serum levels of vitamins and papillary thyroid cancer: a single center case-control study.Gland surgery · 2023Article
- Article
- The Effect of a Gluten-Free Diet on Vitamin D Metabolism in Celiac Disease: The State of the Art.Metabolites · 2023Review
- Relationship Between Serum 25-Hydroxyvitamin D Deficiency and Thyroid Disease in Postmenopausal Women with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main role of vitamin D is to maintain calcium and phosphorus homeostasis, thus preserving bone health. Recent evidence has demonstrated that vitamin D may also have a role in a variety of nonskeletal disorders such as endocrine diseases and in particular type 1 diabetes, type 2 diabetes, adrenal diseases and polycystic ovary syndrome. Low levels of vitamin D have also been associated with thyroid disease, such as Hashimoto's thyroiditis. Similarly, patients with new-onset Graves' disease were found to have decreased 25-hydroxyvitamin D concentrations. Impaired vitamin D signaling has been reported to encourage thyroid tumorigenesis. This review will focus on the role of vitamin D in thyroid diseases, both autoimmune diseases and thyroid cancer, and will summarize the results of vitamin D supplementation studies performed in patients with thyroid disorders. Although observational studies support a beneficial role of vitamin D in the management of thyroid disease, randomized controlled trials are required to provide insight into the efficacy and safety of vitamin D as a therapeutic tool for this dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.