ReviewNatural product reports2015
Syntheses and biological studies of marine terpenoids derived from inorganic cyanide.
Review in Natural product reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 85 citations in OpenAlex.
- Polypharmacology in malaria treatment: single drugs, multiple mechanisms, greater impact.Trends in parasitology · 2026Review
- Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- CspACS catalysis · 2024Article
- A kalihinol analog disrupts apicoplast function and vesicular trafficking inScience (New York, N.Y.) · 2024Article
- Unified Synthesis of 2-Isocyanoallopupukeanane and 9-Isocyanopupukeanane through a "Contra-biosynthetic" Rearrangement.Angewandte Chemie (International ed. in English) · 2024Article
- EnzymaticJournal of the American Chemical Society · 2023Article
- An Enantiospecific Synthesis of Isoneoamphilectane Confirms Its Strained Tricyclic Structure.Journal of the American Chemical Society · 2023Article
- Identification of Isonitrile-Containing Natural Products in Complex Biological Matrices through Ligation with Chlorooximes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Biosynthesis of Isonitrile- and Alkyne-Containing Natural Products.Annual review of chemical and biomolecular engineering · 2022Review
- Probing the Mechanism of Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.Journal of the American Chemical Society · 2022Article
- Evolution of a Short and Stereocontrolled Synthesis of (+)-7,20-Diisocyanoadociane.The Journal of organic chemistry · 2022Article
- Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022Article
- Natural Product Synthesis through the Lens of Informatics.Accounts of chemical research · 2021Review
- Current Understanding toward Isonitrile Group Biosynthesis and Mechanism.Chinese journal of chemistry · 2021Article
- Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites.Bioorganic & medicinal chemistry · 2020Article
- Facile Discovery and Quantification of Isonitrile Natural Products via Tetrazine-Based Click Reactions.Analytical chemistry · 2020Article
- Amphilectene Diterpene Isonitriles and Formamido Derivatives from the Hainan NudibranchMarine drugs · 2019Article
- Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20-Diisocyanoadociane.Angewandte Chemie (International ed. in English) · 2019Article
- Asmic: An Exceptional Building Block for Isocyanide Alkylations.Organic letters · 2018Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Isocyanoterpenes (ICTs) are marine natural products biosynthesized through an unusual pathway that adorns terpene scaffolds with nitrogenous functionality derived from cyanide. The appendage of nitrogen functional groups - isonitriles in particular - onto stereochemically-rich carbocyclic ring systems provides enigmatic, bioactive molecules that have required innovative chemical syntheses. This review discusses the challenges inherent to the synthesis of this diverse family and details the development of the field. We also present recent progress in isolation and discuss key aspects of the remarkable biological activity of these compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.