Evidence map›Paper›PMID 25514592›Full record

ArticleParasite (Paris, France)2014

Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis.

Wenbao Zhang, Shengyue Wang, Donald P McManus

Open access · goldAbstract readComparative Study
In one paragraph

Article in Parasite (Paris, France), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Immunoproteomic Analysis ofPathogens (Basel, Switzerland) · 2021
    Article
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  7. Study on the effect of an ion channel inhibitor "Fluralaner" onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020
    Article
  8. Article
  9. Article
  10. Study onJournal of veterinary research · 2018
    Article
  11. Article
  12. Article
  13. Comparative Proteomic Analysis ofFrontiers in microbiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Wenbao ZhangState Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.
Shengyue WangShanghai-Ministry of Science and Technology Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, PR China.
Donald P McManusMolecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Chinese National Human Genome Center at Shanghai · CNFirst Affiliated Hospital of Xinjiang Medical University · CNQIMR Berghofer Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic echinococcosis (CE) is a cosmopolitan disease caused by the dog tapeworm Echinococcus granulosus. The disease is difficult to diagnose, treat, and control and is responsible for considerable human morbidity and mortality globally. There is an urgent need for new diagnostic tests and new drugs for treatment of CE and the development of a vaccine against adult worms of E. granulosus in dogs. We recently presented a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 proteins. We undertook an extensive comparative analysis of the E. granulosus transcriptome using representative life stages (protoscoleces, cyst germinal cells and membranes, adult worms, and oncospheres) to explore different aspects of tapeworm biology and parasitism. The genome and transcriptome of E. granulosus provide a unique platform for post-genomic research and to facilitate the development of new, effective treatments and interventions for echinococcosis control.

Indexed as

Genes, HelminthGenomeAmino AcidsAnimalsAnthelminticsAntigens, HelminthBile Acids and SaltsChinaDNA, HelminthDog DiseasesDogsDrug DesignEchinococcosisEchinococcus granulosusEchinococcus multilocularisGenomicsAmino AcidsAnthelminticsAntigens, HelminthBile Acids and SaltsDNA, HelminthHelminth ProteinsVaccines

Identifiers

PMID25514592
PMCPMC4267413
OpenAlexW2110578674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.